Evaluation and Listing of the Infant or Child with Kidney Failure

Reference work entry
Part of the Organ and Tissue Transplantation book series (OTT)

Abstract

The evaluation of a child with renal failure for a potential kidney transplant has great importance for the future success of that transplant. The goal of the evaluation is to identify conditions that exist in the candidate that could affect the long-term success of the transplant either by causing a surgical or long-term medical complication. Identifying these conditions during the evaluation process may allow for correction before transplant as well as the preparation for them posttransplantation.

Keywords

Chronic kidney disease Kidney transplant Children ABO incompatibility Infections Immunosuppression Immunization schedule Recurrence Psychosocial Nonadherence 

Abbreviations

BMI

Body mass index

CKD

Chronic kidney disease

CMV

Cytomegalovirus

cPRA

Calculated panel of reactive antibodies

DSA

Donor specific antibodies

EBV

Epstein-Barr virus

eGFR

Calculated or estimated glomerular filtration rate

ESRD

End stage renal disease

FSGS

Focal segmental glomerulosclerosis

HLA

Major histocompatibility complex antigens

HUS

Hemolytic uremic syndrome

LVH

Left ventricular hypertrophy

PRA

Panel of reactive antibodies (%)

VCUG

Voiding cystourethrogram

References

  1. Abecassis M, Bartlett ST, Collins AJ et al (2008) Kidney transplantation as primary therapy for end-stage renal disease: a National Kidney Foundation/Kidney Disease Outcome Quality Initiative (NKF/KDOQI) conference. Clin J Am Soc Nephrol 3:471–480CrossRefPubMedPubMedCentralGoogle Scholar
  2. Abramowicz D, Cochat P, Class FHJ et al (2015) European renal best practice guideline on kidney donor and recipient evaluation and perioperative care. Nephrol Dial Transplant 30:1790–1797CrossRefPubMedGoogle Scholar
  3. Alkhunaizi AM, de Mattos A, Barry JM et al (1999) Renal transplantation across the ABO barrier using A2 kidneys. Transplantation 67:1319–1324CrossRefPubMedGoogle Scholar
  4. Ariceta G, Besbas N, Johnson S et al (2009) Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome. Pediatr Nephrol 24:687–696CrossRefPubMedGoogle Scholar
  5. Avery RK (2002) Recipient screening prior to solid-organ transplantation. Clin Infect Dis 35:1513–1519CrossRefPubMedGoogle Scholar
  6. Avery RK (2004) Prophylactic strategies before solid-organ transplantation. Curr Opin Infect Dis 17:353–356CrossRefPubMedGoogle Scholar
  7. Braun WE (1990) Long-term complications of renal transplantation. Kidney Int 37:1363–1378CrossRefPubMedGoogle Scholar
  8. Briganti EM, Graeme RR, McNeil JJ et al (2002) Risk of renal allograft loss from recurrent glomerulonephritis. N Engl J Med 347:103–109CrossRefPubMedGoogle Scholar
  9. Chapman JR (2013) The recipient of a kidney transplant. In: Morris PJ, Knechtle SJ (eds) Kidney transplantation principles and practice, 7th edn. Saunders Elsevier, Philadelphia, p 62Google Scholar
  10. Chin-Hong PV, Kwak EJ (2013) Human papillomavirus in solid organ transplantation. Am J Transplant 13:189–200Google Scholar
  11. Chisholm-Burns MA, Spivey CA, Rehfeld R et al (2009) Immunosuppressant therapy adherence and graft failure among pediatric renal transplant recipients. Am J Transplant 9:2497–2504Google Scholar
  12. Cochat P, Bernard C, Offner G (2002) European best practice guidelines for transplantation section IV.11 paediatrics (specific problems). Nephrol Dial Transplant 17(suppl 4):55–58Google Scholar
  13. Danziger-Isakov L, Kumar D (2013) Vaccination in solid organ transplantation. Am J Transplant 13:311–317CrossRefPubMedGoogle Scholar
  14. Davis ID, Chang P-N, Nevins TE (1990) Successful renal transplantation accelerates development in young uremic children. Pediatrics 86:594–600PubMedGoogle Scholar
  15. Dobbels F, Ruppar T, DeGeest S et al (2010) Adherence to the immunosuppressive regimen in pediatric kidney transplant recipients: a systematic review. Pediatr Transplant 14:603–613CrossRefPubMedGoogle Scholar
  16. Dube K, Cohen DJ (2014) Recurrent and de novo diseases after renal transplantation. In: Weir MR, Lerma EV (eds) Kidney transplantation practical guide to management. Springer, New York, p 160Google Scholar
  17. Fine RN (1985) Renal transplantation for children-the only realistic choice. Kidney Int 28(suppl 17):S15–S17Google Scholar
  18. Fishman JA (2007) Infection in solid-organ transplant recipients. N Engl J Med 357:2601–2614CrossRefPubMedGoogle Scholar
  19. Foster BJ, Dahhou M, Zhang X et al (2011) Association between age and graft failure rates in young kidney transplant recipients. Transplantation 92:1237–1243CrossRefPubMedGoogle Scholar
  20. Fung E, Shaw RJ (2008) Pediatric transplant rating instrument – a scale for the pretransplant psychiatric evaluation of pediatric organ transplant recipients. Pediatr Transplant 12:57–66CrossRefPubMedGoogle Scholar
  21. Gane E, Pilmore H (2002) Management of chronic viral hepatitis before and after renal transplantation. Transplantation 74:427–437CrossRefPubMedGoogle Scholar
  22. Ghane Sharbaf F, Bitzan M, Szymanski KM et al (2012) Native nephrectomy prior to pediatric kidney transplantation: biological and clinical aspects. Pediatr Nephrol 27:1179–1188CrossRefPubMedPubMedCentralGoogle Scholar
  23. Goldsmith PJ, Asthana S, Fitzpatrick M et al (2010) Transplantation of adult-sized kidneys in low-weight pediatric recipients achieves short-term outcomes comparable to size-match grafts. Pediatr Transplant 14:919–924CrossRefPubMedGoogle Scholar
  24. Hokken-Koelega ACS, Van Zaal MAE, deRidder MAJ et al (1994) Growth after renal transplantation in prepubertal children: impact of various treatment modalities. Pediatr Res 35:367–371CrossRefPubMedGoogle Scholar
  25. Ibrahim HN, Kasiske BL, Matas AJ et al (2012) Donor and recipient issues. In: Taal MW, Chertow GN, Marsden PA (eds) Brenner and Rector’s the kidney, 9th edn. Elsevier Saunders, Philadelphia, page 2496 (a) and page 2498 (b)Google Scholar
  26. Irish A (2004) Hypercoagulabilty in renal transplant recipients. Identifying patients at risk of renal allograft thrombosis and evaluating strategies for prevention. Am J Cardiovasc Drugs 4:139–149CrossRefPubMedGoogle Scholar
  27. Issa N, Krowka MJ, Griffin MD et al (2008) Pulmonary hypertension is associated with reduced patient survival after kidney transplantation. Transplantation 86:1384–1388CrossRefPubMedGoogle Scholar
  28. Kasiske BL, Klinger D (2000) Cigarette smoking in renal transplant recipients. J Am Soc Nephrol 11:753–759PubMedGoogle Scholar
  29. Kasiske BL, Cangro CB, Hariharan S et al (2001) The evaluation of renal transplant candidates: clinical practice guidelines. Am J Transplant 2(suppl 1):5–95CrossRefGoogle Scholar
  30. Khankin EV, Mandelbrot DA (2014) Recipient evaluation. In: Weir MR, Lerma EV (eds) Kidney transplantation practical guide to management. Springer, New York, p 38Google Scholar
  31. Kist-van Holthe JE, Ho PL, Stablein D et al (2005) Outcome of renal transplantation for Wilms’ tumor and Denys-Drash syndrome: a report of the North American Pediatric Renal Transplant Cooperative study. Pediatr Transplant 9:305–310Google Scholar
  32. Knoll G, Cockfield S, Blydt-Hansen T, et al (2005) Canadian Society of Transplantation consensus guidelines on eligibility for kidney transplantation. CMAJ 173 1181- available on line at www.cmaj.ca/cgi/content/full/173/10/1181/DCI
  33. Loirat C, Niaudet P (2003) The risk of recurrence of hemolytic uremic syndrome after renal transplantation in children. Pediatr Nephrol 18:1095–1101CrossRefPubMedGoogle Scholar
  34. Martín-Dávila P, Fortún J, López-Vélez R et al (2008) Transmission of tropical and geographically restricted infections during solid-organ transplantation. Clin Microbiol Rev 21:60–96CrossRefPubMedPubMedCentralGoogle Scholar
  35. McDonald SP, Craig JC (2004) Long-term survival of children with end-stage renal disease. N Engl J Med 350:2654–2662CrossRefPubMedGoogle Scholar
  36. Mendley SR, Zelko FA (1999) Improvement in specific aspects of neurocognitive performances in children after renal transplantation. Kidney Int 56:318–323CrossRefPubMedGoogle Scholar
  37. Molle ZL, Baqi N, Gretch D et al (2002) Hepatitis C infection in children and adolescents with end-stage renal disease. Pediatr Nephrol 17:444–449CrossRefPubMedGoogle Scholar
  38. Montgomery JR, Berger JC, Warren DS et al (2012) Outcomes of ABO-incompatible kidney transplantation in the United States. Transplantation 93:603–609PubMedPubMedCentralGoogle Scholar
  39. Mor E, Weismann I (2009) Current treatment of primary hyperoxaluria type I: when should liver/kidney transplantation be considered. Pediatr Transplant 13:805–807CrossRefGoogle Scholar
  40. Naesens M, Kambham N, Concepcion W et al (2007) The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients. Am J Transplant 7:2504–2514CrossRefPubMedGoogle Scholar
  41. Nicoletto BB, Fonseca NKO, Manfro RC et al (2014) Effects of obesity on kidney transplantation outcomes: a systematic review and meta-analysis. Transplantation 98:167–176CrossRefPubMedGoogle Scholar
  42. Opelz G, Döhler B (2007) Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades. Transplantation 84:137–143CrossRefPubMedGoogle Scholar
  43. Opelz G, Döhler B (2010) Pediatric kidney transplantation: analysis of donor age, HLA match and posttransplant non-Hodgkin lymphoma: a collaborative transplant study report. Transplantation 90:292–297CrossRefPubMedGoogle Scholar
  44. Organ Procurement and Transplantation Network (OPTN) and Scientific Registry of Transplant Recipients (SRTR). OPTN/SRTR 2012 annual data report. http://ustransplant.org. Accessed 1Sept 2015
  45. Patel UD, Thomas SE (2007) Evaluation of the candidate. In: Fine RN, Webber SA, Olthoff KM et al (eds) Pediatric solid organ transplantation, 2nd edn. Backwell, Malden, p 157Google Scholar
  46. Patel RK, Pennington C, Stevens KK et al (2014) Effect of left atrial and ventricular abnormalities on renal transplant outcome- a single center study. Transplant Res 3:20, http://www.transplantationresearch.com/content/3/1/20 CrossRefPubMedPubMedCentralGoogle Scholar
  47. Rianthavorn P, Ettenger RB (2005) Medication non-adherence in the adolescent renal transplant recipient: a clinician’s viewpoint. Pediatr Transplant 9:398–407CrossRefPubMedGoogle Scholar
  48. Rogerson TE, Chen S, Kok J et al (2013) Test for latent tuberculosis in people with ESRD: a systemic review. Am J Kidney Dis 61:33–43CrossRefPubMedGoogle Scholar
  49. Rubin LG, Levin MJ, Ljungman P et al (2014) 2013 IDSA clinical practice guideline for vaccination of the immunocomprised host. Clin Infect Dis 58(3):e44–e100.  https://doi.org/10.1093/cid/cit684, Epub 2013 Dec 4CrossRefPubMedGoogle Scholar
  50. Santín S, Bullich G, Tazón-Vega B et al (2011) Clinical utility of genetic testing in children and adults with steroid-resistant nephrotic syndrome. Clin J Am Soc Nephrol 6:1139–1148CrossRefPubMedPubMedCentralGoogle Scholar
  51. Sapir-Pichhadze R, Wang Y, Famure O et al (2013) Time-dependent variability in tacrolimus trough blood levels is a risk factor for late kidney transplant rejection. Kidney Int 85:1404–1411CrossRefPubMedGoogle Scholar
  52. Scandling JD (2005) Kidney transplant candidate evaluation. Semin Dial 18(6):487–494CrossRefPubMedGoogle Scholar
  53. Scharpé J, Evenepoel P, Maes B et al (2008) Influenza vaccination is efficacious and safe in renal transplant recipients. Am J Transplant 8:332–337CrossRefPubMedGoogle Scholar
  54. Schold JD, Srinivas TR, Guerra G et al (2007) A ‘weight-listing’ paradox for candidates of renal transplantation? Am J Transplant 7:550–559CrossRefPubMedGoogle Scholar
  55. Slickers J, Duquette P, Hooper S et al (2007) Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Pediatr Nephrol 22:565–572CrossRefPubMedGoogle Scholar
  56. Smith JM, Stablein DM, Munoz R et al (2007) Contributions of the transplant registry: the 2006 annual report of the North American Pediatric Renal Trials and Collaborative Studies (NAPRTCS). Pediatr Transplant 11:366–373CrossRefPubMedGoogle Scholar
  57. Stelzmueller I, Wiesmayr S, Swenson BR et al (2007) Rotavirus enteritis in solid organ transplant recipients: an underestimated problem? Transpl Infect Dis 9:281–285CrossRefPubMedGoogle Scholar
  58. Suthanthiran M, Strom TB (1994) Renal transplantation. N Engl J Med 331:365–376CrossRefPubMedGoogle Scholar
  59. Takemoto SK, Terasaki PI, Gjertson DW et al (2000) Twelve years’ experience with national sharing of HLA-matched cadaveric kidney for transplantation. N Engl J Med 343:1078–1084CrossRefPubMedGoogle Scholar
  60. Tejani A, Fine R, Alexander S et al (1993) Factors predictive of sustained growth in children after renal transplantation. J Pediatr 122:397–402CrossRefPubMedGoogle Scholar
  61. Trautmann A, Bodria M, Ozaltin F et al (2015) Spectrum of steroid-resistant and congenital nephrotic syndrome in children: the PodoNet registry cohort. Clin J Am Soc Nephrol 10:592–600CrossRefPubMedPubMedCentralGoogle Scholar
  62. Weber S, Tönshoff B (2005) Recurrence of focal-segmental glomeruloscleroisis in children after renal transplantation: clinical and genetic aspects. Transplantation 80:S128–S134CrossRefPubMedGoogle Scholar
  63. Winterberg P, Warshaw B (2013) Renal transplantation in children. In: Morris PJ, Knechtle SJ (eds) Kidney transplantation: principles and practice, 7th edn. Saunders Elsevier, Philadelphia, page 611 (a), pages 614–620 (b), page 624 (c)Google Scholar
  64. Wood EG, Hand M, Briscoe DM et al (2001) Risk factors for mortality in infants and young children on dialysis. Am J Kidney Dis 37:573–579CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Solid Organ Transplantation, EmeritusAlfred I. duPont Hospital for ChildrenWilmingtonUSA

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