Abstract
Integrative medicine practice includes a combination of current medical therapies in conjunction with practices sometimes referred to as complementary or alternative. Patients undergoing liver transplantation initially are suffering from some type of liver dysfunction pretransplant and also require increased liver support posttransplant. This chapter will focus on current integrative medicine practices such as diet and nutrition, nutritional supplements, acupuncture, and mind-body practices in relation to patients who are planning or have received a liver transplant. The goal is to establish a set of integrative medicine practices that help optimize a patient’s diet and exercise regimen, provide appropriate stress management and coping techniques, and consider the pros and cons of various nutritional supplements commonly used to support liver health.
References
Abd El-Atti S, Wasicek K, Mark S et al (2009) Use of probiotics in the management of chemotherapy-induced diarrhea: a case study. JPEN J Parent Enter Nutr 33:569–570
Ali SA, Aly HF, Faddah LM, Zaidi ZF (2012) Dietary supplementation of some antioxidants against hypoxia. World J Gastroenterol 18(44):6379–6386
Ang-Lee MK, Moss J, Yuan CS (2001) Herbal medicines and perioperative care. JAMA 286:208–216
Anstee QM, Day CP (2012) S-adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility. J Hepatol 57(5):1097–1109
Bargut TC, Frantz ED, Mandarim-de-Lacerda CA, Aguila MB (2014) Effects of a diet rich in n-3 polyunsaturated fatty acids on hepatic lipogenesis and beta-oxidation in mice. Lipids 49(5):431–444
Bishop SR, Lau M, Shapiro S et al (2004) Mindfulness, a proposed operational definition. Clin Psychol Sci Pract 11:230–241
Bitetto D, Fabris C, Falleti E et al (2010) Vitamin D and the risk of acute allograft rejection following human liver transplantation. Liver Int 30(3):417–444
Boleij A, Tjalsma H (2012) Gut bacteria in health and disease: a survey on the interface between intestinal microbiology and colorectal cancer. Biol Rev Camb Philos Soc 87:701–730
Bouzianas DG, Bouziana SD, Hatzitolios AI (2013) Potential treatment of human nonalcoholic fatty liver disease with long-chain omega-3 polyunsaturated fatty acids. Nutr Rev 71(11):753–771
Boyle RJ, Robins-Browne RM, Tang ML (2006) Probiotic use in clinical practice: what are the risks? Am J Clin Nutri 83:1256–1264
Branch AD, Barin B, Rahman A, 2 (2014) Vitamin D status of human immunodeficiency virus-positive patients with advanced liver disease enrolled in the solid organ transplantation in HIV: multi-site study. Liver Transpl 20:156–164
Bunzel B, Laederach-Hofmann K (2000) Solid organ transplantation: are there predictors for posttransplant noncompliance? A literature overview. Transplantation 70(5):711–716
Caglieris S, Giannini E, Dardano G et al (2000) Tauroursodeoxycholic acid administration as adjuvant therapy in cirrhotic patients on transplantation waiting lists. Hepatogastroenterology 47(34):1045–1047
Corey KE, Kaplan LM (2014) Obesity and liver disease: the epidemic of the twenty-first century. Clin Liver Dis 18(1):1–18
Corey RL, Rakela J (2014) Complementary and alternative medicine: risks and special considerations in pretransplant and posttransplant patients. Nutr Clin Pract 29(3):322–331
Corpet DE (2011) Red meat and colon cancer: should we become vegetarians, or can we make meat safer? Meat Sci 89:310–316
de Moreno-de LBA, Matar C, PerdigĂ³n G (2007) The application of probiotics in cancer. Br J Nutr 98:S105–S110
Elshazly SM, El-Moselhy MA, Barakat W (2014) Insights in the mechanism underlying the protective effect of α-lipoic acid against acetaminophen-hepatotoxicity. Eur J Pharmacol 726:116–123
Errington-Evans N (2012) Acupuncture for anxiety. CNS Neurosci Ther 18(4):277–284
Fanti L, Gemma M, Passaretti S et al (2003) Electroacupuncture analgesia for colonoscopy: a prospective, randomized, placebo-controlled study. Am J Gastroenterol 98:312–316
Ferrucci LM, Bell BP, Dhotre KB et al (2010) Complementary and alternative medicine use in chronic liver disease patients. J Clin Gastroenterol 44:e40–e45
Field T (2010) Yoga clinical research review. Complement Ther Clin Pract 17:1–8
Foroncewicz B, Mucha K, Gryszkiewicz J et al (2011) Dietary supplements and herbal preparations in renal and liver transplant recipients. Transplant Proc 43:2935–2937
Gane EJ, Weilert F, Orr DW et al (2010) The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int 30:1019–1026
Giugliano D, Ceriello A, Esposito K (2006) The effects of diet on inflammation – emphasis on the metabolic syndrome. J Am Coll Cardiol 48:67–685
Hofmann SG, Sawyer AT, Witt AA, Oh D (2010) The effect of mindfulness-based therapy on anxiety and depression, a meta-analytic review. J Consult Clin Psychol 78:169–183
Jirillo E, Jirillo F, Magrone T (2012) Healthy effects exerted by prebiotics, probiotics, and symbiotics with special reference to their impact on the immune system. Int J Vitam Nutr Res 82:200–208
Johnston BC, Ma SS, Goldenberg JZ et al (2012) Probiotics for the prevention of Clostridium difficile associated diarrhea: a systematic review and meta-analysis. Ann Intern Med 157:878–888
Kabat-Zinn J, Massion AO, Kristeller J et al (1992) Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders. Am J Psychiatry 149:936–943
Karaivazoglou K, Iconomou G, Triantos C et al (2010) Fatigue and depressive symptoms associated with chronic viral hepatitis patients. Health-related quality of life (HRQOL). Ann Hepatol 9(4):419–427
Kawamura E, Habu D, Morikawa H et al (2009) A randomized pilot trial of oral branched-chain amino acids in early cirrhosis: validation using prognostic markers for pre-liver transplant status. Liver Transpl 15(7):790–797
Kirkwood G, Rampes H, Tuffrey V et al (2005) Yoga for anxiety, a systematic review of the research evidence. Br J Sports Med 39:884–891
Li QS, Cao SH, Xie GM et al (1994) Combined traditional Chinese medicine and Western medicine. Relieving effects of Chinese herbs, ear-acupuncture and epidural morphine on postoperative pain in liver cancer. Chin Med J (Engl) 107(4):289–294
Liu GY, Wang W, Jia WD (2014) Protective effect of S-adenosylmethionine on hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic HBV infection. World J Surg Oncol 12:27
Mai I, Stormer E, Bauer S et al (2003) Impact of St John’s wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients. Nephrol Dial Transplant 18:819–822
Masuda T, Shirabe K, Yoshiya S et al (2013) Nutrition support and infections associated with hepatic resection and liver transplantation in patients with chronic liver disease. JPEN J Parenter Enteral Nutr 37(3):318–326
Michalsen A, Grossman P, Acil A et al (2005) Rapid stress reduction and anxiolysis among distressed women as a consequence of a three-month intensive yoga programme. Med Sci Monit 11:555–561
Monti DA, Bazzan AJ (2008) The great life makeover. Collins Living, New York
Monti DA, Kash K, Kunkel EJ et al (2013) Psychosocial benefits of a novel mindfulness intervention versus standard support in distressed women with breast cancer. Psychooncology 22(11):2565–2575
Montonen J, Boeing H, Fritsche HA et al (2012) Consumption of red meat and whole-grain bread in relation to biomarkers of obesity, inflammation, glucose metabolism and oxidative stress. Eur J Nutr 52:337–345
Mullin GE (2013a) The use of complementary and alternative medicine for liver disease: part I. Nutr Clin Pract 28:138–139
Mullin GE (2013b) The use of complementary and alternative medicine for liver disease: part II. Nutr Clin Pract 28:277–279
Nagata S, Shirabe K, Sugimachi K et al (2013) Pilot study of preoperative immunonutrition with antioxidants in living donor liver transplantation donors. Fukuoka Igaku Zasshi 104:530–538
Ospina MB, Bond TK, Karkhaneh M et al (2007) Meditation practices for health, state of the research. Agency for Healthcare Research and Quality, Rockville. Evidence report/technology assessment no. 155
Pantoflicek T, Koblihova E, Ryska M (2012) S-adenosylmethionine does not reduce ischaemia-reperfusion injury to a marginal liver graft in an in vivo experiment. Hepatogastroenterology 59(113):216–218
Plank LD, Mathur S, Gane EJ et al (2012) Perioperative immunonutrition in patients undergoing liver transplantation: a randomized double-blind trial. Hepatology. doi:10.1002/hep.27433
Rao MR, Raghuram N, Nagendra HR et al (2009) Anxiolytic effects of a yoga program in early breast cancer patients undergoing conventional treatment. A randomized controlled trial. Complement Ther Med 17:1–8
Rayes N, Seehofer D, Theruvath T et al (2005) Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation – a randomized, double-blind trial. Am J Transplant 5:125–130
Robinson SM, Saif R, Sen G et al (2013) N-acetylcysteine administration does not improve patient outcome after liver resection. HPB (Oxford) 15(6):457–462
Sarno G, Mehta RJ, Guardado-Mendoza R et al (2013) New-onset diabetes mellitus: predictive factors and impact on the outcome of patients undergoing liver transplantation. Curr Diabetes Rev 9(1):78–85
Sheikh-Ali M, Keaveny AP, Chamseddin A et al (2014) 25-hydroxyvitamin d levels and acute cellular rejection in liver transplant patients. Endocr Pract 20(8):769–774
Stanger MJ, Thompson LA, Young AJ, Lieberman HR (2012) Anticoagulant activity of select dietary supplements. Nutr Rev 70:107–117
Strader DB, Bacon BR, Lindsay KL et al (2002) Use of complementary and alternative medicine in patients with liver disease. Am J Gastroenterol 97(9):2391–2397
Sumantran VN, Tillu G (2012) Cancer, inflammation, and insights from ayurveda. Evid Based Complement Alternat Med 2012:306346. doi:10.1155/2012/306346
Sumimoto K, Inagaki K, Ito H, 5 (1987) Ischemic damage prevention by coenzyme Q10 treatment of the donor before orthotopic liver transplantation: biochemical and histologic findings. Surgery 102:821–827
Tang FY, Pai MH, Chiang EP (2012) Consumption of high-fat diet induces tumor progression and epithelial-mesenchymal transition of colorectal cancer in a mouse xenograft model. J Nutr Biochem 23:1302–1313
Tang Y, Zhang W, Zhang Y et al (2014) 5′-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation 37:1366–1373
Togo S, Tanaka K, Morioka D et al (2005) Usefulness of granular BCAA after hepatectomy for liver cancer complicated with liver cirrhosis. Nutrition 21(4):480–486
Toneatto T, Nguyen L (2007) Does mindfulness meditation improve anxiety and mood symptoms? A review of the controlled research. Can J Psychiatry 52:260–266
Vanden Heuvel JP (2012) Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids. Prog Mol Biol Transl Sci 108:75–112
Wanchai A, Armer JM, Stewart BR (2010) Complementary and alternative medicine use among women with breast cancer: a systematic review. Clin J Oncol Nurs 14:E45–E55
Wang SM, Peloquin C, Kain ZN (2001) The use of auricular acupuncture to reduce preoperative anxiety. Anesth Analg 93:1178–1180
Xia X, Su C, Fu J et al (2014) Role of α-lipoic acid in LPS/d-GalN induced fulminant hepatic failure in mice: studies on oxidative stress, inflammation and apoptosis. Int Immunopharmacol 22:293–302
Yang Y, Li W, Liu Y et al (2014) Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. doi:10.1016/j.jnutbio.2014.06.001. pii: S0955-2863(14)00133-8 [Epub ahead of print]
Zhou J, Liang Y, Lin XM et al (2012) Acupuncture in treating hepatic fibrosis: a review with recommendation for future studies. Afr J Tradit Complement Altern Med 9(4):452–458
Zhu M, Sun W (1998) The effects of acupuncture at Zusanli and Guanyuan on the model rats with hepatic fibrosis. J Mudanjiang Med Coll 19:1–3
Zhu XH, Wu YF, Qiu YD et al (2012) Liver-protecting effects of omega-3 fish oil lipid emulsion in liver transplantation. World J Gastroenterol 18:6141–6147
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this entry
Cite this entry
Bazzan, A.J., Newberg, A.B., Monti, D.A. (2017). Role of Integrative Medicine in Liver Transplantation. In: Doria, C. (eds) Contemporary Liver Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-07209-8_31
Download citation
DOI: https://doi.org/10.1007/978-3-319-07209-8_31
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-07208-1
Online ISBN: 978-3-319-07209-8
eBook Packages: MedicineReference Module Medicine