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Cell Therapy for Liver Failure: A New Horizon

  • Reference work entry
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Contemporary Liver Transplantation

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

Liver failure is the seventh largest cause of death in industrialized countries. The only available cure, liver transplantation, is severely limited by a lack of donors and further complicated by the adverse effects of chronic immune suppression. Molecular mechanisms associated with the process of liver regeneration and the role of various progenitor cells in healing injury will be discussed in this chapter. Preclinical and clinical data will be reviewed from studies involving bone marrow mesenchymal stem cells (BM-MSC), adipose tissue MSC (AT-MSC), and bone marrow mononuclear cells (BMMC) including their purified subsets. From analyzing published clinical trials, it appears that there is some efficacy utilizing autologous cells, but these seem to be limited to a timeframe of less than a year. Promising sources of MSC such as the umbilical cord and fetal liver cells which have been used in allogeneic settings will also be described.

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  1. Medistem Panama, Inc, Panama City, Panama

    Neil H. Riordan

  2. Riordan-McKenna Institute, Southlake, TX, USA

    Neil H. Riordan

  3. Aidan Foundation, Chandler, AZ, USA

    Neil H. Riordan

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  1. Nicoletti Family Professor of Transplant Surgery, Director, Jefferson Transplant Institute, Director, Division of Transplantation, Surgical Director, Kimmel Cancer Center – Jefferson Liver Tumor Center, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA

    Cataldo Doria

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Riordan, N.H. (2017). Cell Therapy for Liver Failure: A New Horizon. In: Doria, C. (eds) Contemporary Liver Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-319-07209-8_25

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