Abstract
There is a delicate balance between thrombosis and hemostasis – primary hemostasis (platelet plug), secondary hemostasis (fibrin clot), and fibrinolysis. On the coagulation side, a balance between procoagulants and anticoagulants and pro-fibrinolytics and anti-fibrinolytics is crucial to maintain physiological hemostasis. Similarly, on the platelet side, a balance between endogenous platelet activators and inhibitors is also critical in the maintenance of hemostasis. When using either antiplatelet or anticoagulants to prevent or treat either arterial or venous thrombosis, a risk of bleeding exists due to the shift in the balance between thrombosis and hemostasis.
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Template Bleeding Time Method
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© 2016 Springer International Publishing Switzerland
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Mousa, S.A. (2016). Hemostasis Models: Bleeding Models. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Cham. https://doi.org/10.1007/978-3-319-05392-9_14
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DOI: https://doi.org/10.1007/978-3-319-05392-9_14
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-05391-2
Online ISBN: 978-3-319-05392-9
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