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Encyclopedia of Inflammatory Diseases pp 1–9Cite as

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Diffuse Panbronchiolitis

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Synonyms

DPB

Definition

Diffuse panbronchiolitis (DPB) is an inflammatory lung disease, characterized by the chronic inflammation of bronchioles (small airways) in both lungs (Homma et al. 1983). The term diffuse means that lesions appear throughout both lungs, while panbronchiolitis refers to inflammation found in the respiratory bronchioles. DPB causes severe coughing, large amounts of sputum, and exertional breathlessness, often associated with chronic sinusitis, ultimately leading to respiratory failure. Histopathologically, thickened walls of terminal bronchioles, with infiltration of lymphocytes, plasma cells, and foamy macrophages, leading to chronic neutrophilic inflammatory airway disease, are the predominant features (Homma et al. 2006). Eventually, DPB develops into bronchiectasis, if left untreated, and the result will be fatal. The disease was first described by a Japanese group of clinicians as a new entity in the 1960s. It had not been accepted internationally because...

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References

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Authors and Affiliations

  1. Respiratory Disease Center, Yokohama City University Medical Center, 4-57, Urafune-cho, Minami-ku, Yokohama, 232-0024, Yokohama City, Japan

    Masaharu Shinkai & Yoriko Inoue

Authors
  1. Masaharu Shinkai
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  2. Yoriko Inoue
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Corresponding authors

Correspondence to Masaharu Shinkai or Yoriko Inoue .

Editor information

Editors and Affiliations

  1. Inst of Clinical Pharmacology Haus 74/75, JW Goethe University Frankfurt Fraunhofer IME, Frankfurt, Germany

    Michael Parnham

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© 2016 Springer Basel

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Shinkai, M., Inoue, Y. (2016). Diffuse Panbronchiolitis. In: Parnham, M. (eds) Encyclopedia of Inflammatory Diseases. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-0620-6_190-2

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  • DOI: https://doi.org/10.1007/978-3-0348-0620-6_190-2

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  • Publisher Name: Birkhäuser, Basel

  • Online ISBN: 978-3-0348-0620-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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