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Anaphylaxis (Immediate Hypersensitivity): From Old to New Mechanisms

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Compendium of Inflammatory Diseases

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Synonyms

Allergic shock; Systemic type I immediate hypersensitivity reaction

Anaphylaxis: Definition and Historical Perspectives

Anaphylaxis is a severe and potentially fatal systemic allergic reaction that occurs immediately after contact with the provocative substance (allergen). The most common causative agents are food and drugs; however, an equivalently large proportion of cases (20 %) are idiopathic. Although there continues to be a dramatic increase in prevalence of anaphylaxis worldwide (Koplin et al. 2011), our understanding of the responsible immune mechanisms remains incomplete. As a clinical condition, variable presentation and heterogeneity in terminology, criteria, and definitions have led to inconsistent diagnoses of anaphylaxis, and further confound attempts to understand the underlying pathogenesis. Recent efforts to define the diagnostic criteria for an anaphylactic reaction consider the involvement of multiple organ systems: primarily the skin or mucosal tissue,...

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Authors and Affiliations

  1. Institut Pasteur, Department of Immunology, Unit of Antibodies in Therapy and Pathology, 25, rue du Docteur Roux, 75015, Paris, France

    Caitlin M. Gillis, Aurélie Gouel-Chéron & Pierre Bruhns

  2. INSERM, U1222, 46, rue Henri Huchard, 75877 Cedex 18, Paris, France

    Caitlin M. Gillis, Aurélie Gouel-Chéron & Pierre Bruhns

  3. Université Pierre et Marie Curie, 25, rue du Docteur Roux, 75015, Paris, France

    Caitlin M. Gillis & Aurélie Gouel-Chéron

Authors
  1. Caitlin M. Gillis
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  2. Aurélie Gouel-Chéron
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  3. Pierre Bruhns
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Correspondence to Pierre Bruhns .

Editor information

Editors and Affiliations

  1. Inst of Clinical Pharmacology Haus 74/75, JW Goethe University Frankfurt Fraunhofer IME, Frankfurt, Germany

    Michael Parnham

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Gillis, C.M., Gouel-Chéron, A., Bruhns, P. (2015). Anaphylaxis (Immediate Hypersensitivity): From Old to New Mechanisms. In: Parnham, M. (eds) Compendium of Inflammatory Diseases. Birkhäuser, Basel. https://doi.org/10.1007/978-3-0348-0620-6_115-2

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  • DOI: https://doi.org/10.1007/978-3-0348-0620-6_115-2

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  • Publisher Name: Birkhäuser, Basel

  • Online ISBN: 978-3-0348-0620-6

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