2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Sclerosing Adenosis of the Prostate

  • Alessia Cimadamore
  • Liang Cheng
  • Rodolfo MontironiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_5012


Sclerosing adenosis (SA) of the prostate is a benign, small, acinar proliferation of well-formed glands in dense spindle cell stroma, with a distinct immunohistochemical profiles (Berney et al. 2007; Collina et al. 1992; Grignon et al. 1992; Herawi et al. 2005; Jones et al. 1991).

Clinical Features

  • Incidence

    It is incidentally found in about 2% of TURP specimens.

  • Age

    Usually in the age of benign prostatic hyperplasia.

  • Sex


  • Site

    Central zone.

  • Treatment


  • Outcome



Not identifiable.


Small microacini, solid clusters, cords, and single cells are seen in a background of cellular spindle cell stroma. Glands are lined by cells with clear or amphophilic cytoplasm and nuclei without prominent nucleoli. Sclerosing adenosis with significant cytological atypia mimics adenocarcinoma. Presence of an intact basal cell layer allows to distinguish it from PCa (Fig. 1) (Berney et al. 2007; (Cheng and Bostwick 2010; Collina et al. 1992; Grignon et al. 1992;...
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References and Further Reading

  1. Berney, D. M., Fisher, G., Kattan, M. W., et al. (2007). Pitfalls in the diagnosis of prostatic cancer: Retrospective review of 1791 cases with clinical outcome. Histopathology, 51, 452–457.PubMedCrossRefGoogle Scholar
  2. Cheng, L., & Bostwick, D. G. (2010). Atypical sclerosing adenosis of the prostate: A rare mimic of adenocarcinoma. Histopathology, 56(5), 627–631.PubMedCrossRefGoogle Scholar
  3. Collina, G., Botticelli, A. R., Martinelli, A. M., Fano, R. A., & Trentini, G. P. (1992). Sclerosing adenosis of the prostate. Report of three cases with electronmicroscopy and immunohistochemical study. Histopathology, 20, 505–510.PubMedCrossRefGoogle Scholar
  4. Grignon, D. J., Ro, J. Y., Srigley, J. R., Troncoso, P., Raymond, A. K., & Ayala, A. G. (1992). Sclerosing adenosis of the prostate gland. A lesion showing myoepithelial differentiation. American Journal of Surgical Pathology, 16, 383–391.PubMedCrossRefGoogle Scholar
  5. Herawi, M., Parwani, A. V., Irie, J., & Epstein, J. I. (2005). Small glandular proliferations on needle biopsies: Most common benign mimickers of prostatic adenocarcinoma sent in for expert second opinion. The American Journal of Surgical Pathology, 29, 874–880.PubMedCrossRefGoogle Scholar
  6. Jones, E. C., Clement, P. B., & Young, R. H. (1991). Sclerosing adenosis of the prostate gland. A clinicopathological and immunohistochemical study. American Journal of Surgical Pathology, 15, 1171–1180.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Alessia Cimadamore
    • 1
  • Liang Cheng
    • 2
  • Rodolfo Montironi
    • 1
    Email author
  1. 1.Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona)United Hospitals AnconaAnconaItaly
  2. 2.Department of Pathology and Laboratory MedicineIndiana University School of MedicineIndianapolisUSA