Skip to main content
SpringerLink
Log in

Sclerosing Adenosis of the Prostate

  • Reference work entry
  • First Online:
Uropathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 7 Accesses

Definition

Sclerosing adenosis (SA) of the prostate is a benign, small, acinar proliferation of well-formed glands in dense spindle cell stroma, with a distinct immunohistochemical profiles (Berney et al. 2007; Collina et al. 1992; Grignon et al. 1992; Herawi et al. 2005; Jones et al. 1991).

Clinical Features

  • Incidence

    It is incidentally found in about 2% of TURP specimens.

  • Age

    Usually in the age of benign prostatic hyperplasia.

  • Sex

    Male.

  • Site

    Central zone.

  • Treatment

    None.

  • Outcome

    Benign.

Macroscopy

Not identifiable.

Microscopy

Small microacini, solid clusters, cords, and single cells are seen in a background of cellular spindle cell stroma. Glands are lined by cells with clear or amphophilic cytoplasm and nuclei without prominent nucleoli. Sclerosing adenosis with significant cytological atypia mimics adenocarcinoma. Presence of an intact basal cell layer allows to distinguish it from PCa (Fig. 1) (Berney et al. 2007; (Cheng and Bostwick 2010; Collina et al. 1992; Grignon et al. 1992;...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 329.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 449.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References and Further Reading

  • Berney, D. M., Fisher, G., Kattan, M. W., et al. (2007). Pitfalls in the diagnosis of prostatic cancer: Retrospective review of 1791 cases with clinical outcome. Histopathology, 51, 452–457.

    Article  CAS  PubMed  Google Scholar 

  • Cheng, L., & Bostwick, D. G. (2010). Atypical sclerosing adenosis of the prostate: A rare mimic of adenocarcinoma. Histopathology, 56(5), 627–631.

    Article  PubMed  Google Scholar 

  • Collina, G., Botticelli, A. R., Martinelli, A. M., Fano, R. A., & Trentini, G. P. (1992). Sclerosing adenosis of the prostate. Report of three cases with electronmicroscopy and immunohistochemical study. Histopathology, 20, 505–510.

    Article  CAS  PubMed  Google Scholar 

  • Grignon, D. J., Ro, J. Y., Srigley, J. R., Troncoso, P., Raymond, A. K., & Ayala, A. G. (1992). Sclerosing adenosis of the prostate gland. A lesion showing myoepithelial differentiation. American Journal of Surgical Pathology, 16, 383–391.

    Article  CAS  Google Scholar 

  • Herawi, M., Parwani, A. V., Irie, J., & Epstein, J. I. (2005). Small glandular proliferations on needle biopsies: Most common benign mimickers of prostatic adenocarcinoma sent in for expert second opinion. The American Journal of Surgical Pathology, 29, 874–880.

    Article  PubMed  Google Scholar 

  • Jones, E. C., Clement, P. B., & Young, R. H. (1991). Sclerosing adenosis of the prostate gland. A clinicopathological and immunohistochemical study. American Journal of Surgical Pathology, 15, 1171–1180.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), United Hospitals Ancona, Ancona, Italy

    Alessia Cimadamore & Rodolfo Montironi

  2. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    Liang Cheng

Authors
  1. Alessia Cimadamore
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Liang Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rodolfo Montironi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rodolfo Montironi .

Editor information

Editors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Cimadamore, A., Cheng, L., Montironi, R. (2020). Sclerosing Adenosis of the Prostate. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_5012

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-41894-6_5012

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41893-9

  • Online ISBN: 978-3-030-41894-6

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation