Synonyms
Lentiginosis Pigmented melanocytosis and prostatic nevohyperplasia
Definition
Abnormal or excessive deposition of melanin pigment within cells and/or tissues.
Clinical Features
Incidence
Melanosis of the urinary tract is a rare condition, with few reported cases (Sanborn et al. 2009; Patel et al. 2013).
Prostatic melanosis is extremely rare with approximately 20 cases reported (Klock et al. 2010).
Genital melanosis is a relatively infrequent condition with an estimated reported incidence to be as low as 0.011% of dermatologic patients. Incidence is increased in patients with a history of melanoma (Haugh et al. 2017).
Age
In melanosis of the urinary tract, patient age ranges from childhood to old age.
Prostate melanosis has been described in middle-aged and old men.
Penile melanosis arises in adults or in the elderly, with only few cases reported under 20 years of age (Barnhill et al. 1990).
Sex
Not applicable.
Site
Urogenital melanosis has been described in the urinary tract,...
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References and Further Reading
Barnhill, R. L., Albert, L. S., Shama, S. K., Goldenhersh, M. A., Rhodes, A. R., & Sober, A. J. (1990). Genital lentiginosis: A clinical and histopathologic study. Journal of American Academy of Dermatology, 22, 453–460.
Haugh, A. M., Merkel, E. A., Zhang, B., Bubley, J. A., Verzì, A. E., Lee, C. Y., & Gerami, P. (2017). A clinical, histologic, and follow-up study of genital melanosis in men and women. Journal of American Academy of Dermatology, 76, 836–840.
Klock, C., Gomes, R., Joao, M., & Netto, G. (2010). Prostate melanosis associated with acinar adenocarcinoma. International Journal of Surgical Pathology, 18, 379–380.
Patel, P., Gotto, G., Kavanagh, A., Al Bashir, S., Bismar, T. A., & Trpkov, K. (2013). Urinary bladder melanosis associated with urothelial urothelial dysplasia and invasive urothelial carcinoma: A report of two cases. Analytical and quantitative cytopathology and histopathology. Analytical and quantitative cytopathology and histopathology, 35, 294–300.
Sanborn, S. L., MacLennan, G., Cooney, M. M., Zhou, M., & Ponsky, L. E. (2009). High-grade transitional cell carcinoma and melanosis of urinary bladder: Case report and review of the literature. Urology, 73, 928.e13–928.e15.
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Portelli, F., Trambaiolo Antonelli, C., De Giorgi, V. (2020). Melanosis, Genitourinary Tract. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_5011
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DOI: https://doi.org/10.1007/978-3-030-41894-6_5011
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