2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Melanosis, Genitourinary Tract

  • Francesca PortelliEmail author
  • Chiara Trambaiolo Antonelli
  • Vincenzo De Giorgi
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_5011


Lentiginosis Pigmented melanocytosis and prostatic nevohyperplasia


Abnormal or excessive deposition of melanin pigment within cells and/or tissues.

Clinical Features

  • Incidence

    Melanosis of the urinary tract is a rare condition, with few reported cases (Sanborn et al. 2009; Patel et al. 2013).

    Prostatic melanosis is extremely rare with approximately 20 cases reported (Klock et al. 2010).

    Genital melanosis is a relatively infrequent condition with an estimated reported incidence to be as low as 0.011% of dermatologic patients. Incidence is increased in patients with a history of melanoma (Haugh et al. 2017).

  • Age

    In melanosis of the urinary tract, patient age ranges from childhood to old age.

    Prostate melanosis has been described in middle-aged and old men.

    Penile melanosis arises in adults or in the elderly, with only few cases reported under 20 years of age (Barnhill et al. 1990).

  • Sex

    Not applicable.

  • Site

    Urogenital melanosis has been described in the urinary tract,...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Barnhill, R. L., Albert, L. S., Shama, S. K., Goldenhersh, M. A., Rhodes, A. R., & Sober, A. J. (1990). Genital lentiginosis: A clinical and histopathologic study. Journal of American Academy of Dermatology, 22, 453–460.CrossRefGoogle Scholar
  2. Haugh, A. M., Merkel, E. A., Zhang, B., Bubley, J. A., Verzì, A. E., Lee, C. Y., & Gerami, P. (2017). A clinical, histologic, and follow-up study of genital melanosis in men and women. Journal of American Academy of Dermatology, 76, 836–840.CrossRefGoogle Scholar
  3. Klock, C., Gomes, R., Joao, M., & Netto, G. (2010). Prostate melanosis associated with acinar adenocarcinoma. International Journal of Surgical Pathology, 18, 379–380.PubMedCrossRefGoogle Scholar
  4. Patel, P., Gotto, G., Kavanagh, A., Al Bashir, S., Bismar, T. A., & Trpkov, K. (2013). Urinary bladder melanosis associated with urothelial urothelial dysplasia and invasive urothelial carcinoma: A report of two cases. Analytical and quantitative cytopathology and histopathology. Analytical and quantitative cytopathology and histopathology, 35, 294–300.PubMedGoogle Scholar
  5. Sanborn, S. L., MacLennan, G., Cooney, M. M., Zhou, M., & Ponsky, L. E. (2009). High-grade transitional cell carcinoma and melanosis of urinary bladder: Case report and review of the literature. Urology, 73, 928.e13–928.e15.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Francesca Portelli
    • 1
    Email author
  • Chiara Trambaiolo Antonelli
    • 2
  • Vincenzo De Giorgi
    • 3
  1. 1.Section of Anatomical Pathology, Department of Health SciencesAzienda Ospedaliero-Universitaria Careggi, University of FlorenceFlorenceItaly
  2. 2.Departments of Anatomical Pathology and of Oncology, Ospedale Policlinico San MartinoUniversity of GenoaGenoaItaly
  3. 3.Dermatologic ClinicUniversity of FlorenceFlorenceItaly