Malakoplakia, Genitourinary Tract
- 5 Downloads
Soft yellow plaque
It is an inflammatory lesion resulting in histiocytic accumulation, which is related to impaired intraphagosomal digestion.
Uncommon lesion associated with E. Coli bacterial infection. It may be related to concurrent acute inflammation and immunosuppression (Long and Althausen 1989).
The peak incidence is in the fifth decade, with only anecdotal cases described in children (Krauel et al. 2009).
Female/male – 3:1
The urinary bladder is the most common location of malakoplakia in the genitourinary organs. Rare locations of the disease include the renal pelvis and ureter and the renal parenchyma (Trillo et al. 1977). Epididymis may be involved, as may also be seen in the prostate, with less than 50 reported cases (Wagner et al. 2007).
Localized or radical resection may be necessary together with adjuvant antibiotic therapy. The uncommon ureteric malakoplakia may cause obstruction and hydronephrosis.