2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Granular Cell Tumor, Genitourinary Tract

  • Cecilia Taverna
  • Alessandro FranchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_5007


Granular cells myoblastoma (obsolete)


Granular cell tumor (GCT) is a benign neuroectodermal tumor composed by large polygonal cells with abundant granular cytoplasm (Gurzu et al. 2015). The lesion is usually benign, even though rare malignant cases are reported (Richmond et al. 2016; Fanburg-Smith et al. 1998).

Clinical Features

  • Incidence

    Granular cell tumor is quite rare in the male genitourinary tract. Indeed, 17 cases are reported in the bladder and < 20 cases in male genitalia (Bedir et al. 2017; Pu et al. 2015).

  • Age

    The lesion can occur at all ages (bladder 14–70 years, external male genitalia 6–89) (Cheville and Folpe 2016; Richmond et al. 2016; Pu et al. 2015).

  • Sex

    In the bladder, it occurs in both males and females, while in the external genitalia occurs only in males (Cheville and Folpe 2016; Bedir et al. 2017; Pu et al. 2015; Richmond et al. 2016).

  • Site

    The tumor can occur in the bladder, urethra, external genital tract (penis and scrotum), and...

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References and Further Reading

  1. Bedir, R., Yılmaz, R., Özdemir, O., & Uzun, H. (2017). Granular cell tumor of the urinary bladder. Turkish Journal of Urology, 43(3), 383–385.CrossRefGoogle Scholar
  2. Cheville, J., & Folpe, A. (2016). Tumours of the genitourinary tract in WHO classification of tumours of the urinary system and male genital organs (4th edn, pp. 122–127). IARC, Lyon.Google Scholar
  3. Fanburg-Smith, J. C., Meis-Kindblom, J. M., Fante, R., & Kindblom, L. G. (1998). Malignant granular cell tumor of soft tissue: Diagnostic criteria and clinicopathologic correlation. The American Journal of Surgical Pathology, 22(7), 779–794.CrossRefGoogle Scholar
  4. Gurzu, S., Ciortea, D., Tamasi, A., Golea, M., Bodi, A., Sahlean, D. I., Kovecsi, A., & Jung, I. (2015). The immunohistochemical profile of granular cell (Abrikossoff) tumor suggests an endomesenchymal origin. Archives of Dermatological Research, 307(2), 151–157.CrossRefGoogle Scholar
  5. Pu, C. X., Gao, L., Bai, Y. J., & Han, P. (2015). Granular cell tumor of the urethra: A case report and literature review. Asian Journal of Andrology, 18(6), 946–948.PubMedCentralGoogle Scholar
  6. Richmond, A. M., La Rosa, F. G., & Said, S. (2016). Granular cell tumor presenting in the scrotum of a pediatric patient: A case report and review of the literature. Journal of Medical Case Reports, 10(1), 161.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Health SciencesUniversity of FlorenceFlorenceItaly
  2. 2.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly