2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran


  • Alessandro FranchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_5005


Lymphangioma is a benign proliferation of lymphatic vessels.

Clinical Features

  • Incidence

    Lymphangiomas of the urogenital tract are exceptionally rare.

  • Age

    Lymphangiomas are detected mainly in children and young adults.

  • Sex

    No gender predilection is reported.

  • Site

    A superficial microcystic variant (lymphangioma circumscriptum) and a deep macrocystic variant (cavernous lymphangioma) can be recognized. Lymphangioma circumscriptum may exceptionally occur in the penoscrotal region, while cystic lymphangioma may arise in the kidney and urinary tract, including the urethra and the bladder.

  • Treatment

    The standard treatment is radical surgical resection.

  • Outcome

    No recurrence is usually noted after complete removal of the lesion.


Lymphangioma circumscriptum presents with multiple, grouped, translucent vesicles that may sometimes become pink or red because of hemorrhage from adjacent capillaries. A hyperkeratotic, verrucous surface may develop in older lesions. Deep...

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References and Further Reading

  1. Daklan, S., & Daryakar, A. (2018). Lymphangioma circumscriptum of glans penis: A report of two cases. Dermatology Online Journal, 24(8). pii: 13030/qt9pr342qv.Google Scholar
  2. Laurent, F., Joullie, M., Biset, J. M., Simon, J. M., & Drouillard, J. (1991). Cystic lymphangioma of the kidney: A rare cause of multiloculated renal masses. European Journal of Radiology, 12, 67–68.CrossRefGoogle Scholar
  3. Macki, M., Anand, S. K., Jaratli, H., & Dabaja, A. A. (2019). Penile Lymphangioma: Review of the literature with a case presentation. Basic and Clinical Andrology, 29, 1.CrossRefGoogle Scholar
  4. Mehta, V., Ananthanarayanan, V., Antic, T., Krausz, T., Milner, J., Venkataraman, G., & Picken, M. M. (2012). Primary benign vascular tumors and tumorlike lesions of the kidney: A clinicopathologic analysis of 15 cases. Virchows Archiv, 461, 669–676.CrossRefGoogle Scholar
  5. Niu, Z. B., Yang, Y., Hou, Y., Chen, H., Liu, X., & Wang, C. L. (2010). Lymphangioma of bladder. Urology, 76, 955–957.CrossRefGoogle Scholar
  6. Topaloglu, H., Karakoyunlu, N., Ozok, U., Dilli, A., Onder, E., Sagnak, L., & Ersoy, H. (2013). Lymphangioma of pyeloureteral junction: An extremely rare case. Urologia Internationalis, 90, 243–245.CrossRefGoogle Scholar
  7. Wyler, S. F., Bachmann, A., Singer, G., Gasser, T. C., & Sulser, T. (2004). First case of lymphangioma of the bladder in an adult. Urologia Internationalis, 73, 374–375.CrossRefGoogle Scholar
  8. Zapzalka, D. M., Krishnamurti, L., Manivel, J. C., & DiSandro, M. J. (2002). Lymphangioma of the renal capsule. The Journal of Urology, 168, 220.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly