2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Glomus Tumor

  • Cecilia Taverna
  • Alessandro FranchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_5002


Glomangioma; Glomangiomyoma


Glomus tumor is a rare mesenchymal lesion, first described by Paul Masson in 1924, derived from modified myoid cells of glomus body, an arteriovenous anastomosis of the dermis involved in thermoregulation and skin circulation. Glomus tumor refers to a spectrum of lesions that comprises solid benign glomus tumor, glomangioma, and glomangiomyoma on the basis of the proportion of the various components of the lesions, glomus cells, vascular structures, and smooth muscle cells. Usually the lesion is benign, even though glomus tumor with uncertain potential of malignancy and malignant glomus tumor are described (1% of all glomus tumors). The majority of the cases of glomus tumor are solitary and sporadic, while 10% are multiple and associate to mutation of glomulin gene (chromosome 1p21–22) or to neurofibromatosis (Dagur et al. 2016; Palmisano et al. 2018; Khalafalla et al. 2017; He et al. 2016; Szumilo et al. 2011).

Clinical Features

  • Incidence

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References and Further Reading

  1. Dagur, G., Warren, K., Miao, Y., Singh, N., Suh, Y., & Khan, S. A. (2016). Unusual glomus tumor of the penis. Current Urology, 9(3), 113–118.CrossRefGoogle Scholar
  2. Folpe, A. L., Fanburg-Smith, J. C., Miettinen, M., & Weiss, S. W. (2001). Atypical and malignant glomus tumors: Analysis of 52 cases, with a proposal for the reclassification of glomus tumors. The American Journal of Surgical Pathology, 25(1), 1–12.CrossRefGoogle Scholar
  3. He, T., Hu, J., Jin, L. U., Li, Y., Liu, J., Ding, Y., & Lai, Y. (2016). Glomus tumor of the anterior urethra: A rare case report and review of the literature. Molecular and Clinical Oncology, 4(6), 1057–1059.CrossRefGoogle Scholar
  4. Khalafalla, K., Al-Ansari, A., Omran, A., Farghaly, H., & Alobaidy, A. (2017). Glomus tumor of the scrotum: A case report and mini-review. Current Urology, 10(4), 213–216.CrossRefGoogle Scholar
  5. Masson, P. (1924). Le glomus neuromyoarterial des regions tactiles et ses tumeurs. Lyon Chirurgical, 21, 257.Google Scholar
  6. Palmisano, F., Gadda, F., Spinelli, M. G., Maggioni, M., Rocco, B., & Montanari, E. (2018). Symplastic glomus tumor of the urinary bladder treated by robot-assisted partial cystectomy: A case report and literature review. Urologia, 85(3), 130–132.CrossRefGoogle Scholar
  7. Szumilo, J., Fronczek, A., Lewkowicz, D., & Osemlak, P. (2011). Multiple glomangiomas involving the glans penis in pediatric patient. Journal of Lower Genital Tract Disease, 15(3), 250–253.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Health SciencesUniversity of FlorenceFlorenceItaly
  2. 2.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly