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Urinary Tract Adenocarcinoma

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  • First Online:
Uropathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 6 Accesses

Synonyms

Adenocarcinoma of the urinary tract; Invasive adenocarcinoma

Definition

Primary tumor with pure glandular phenotype which originates de novo within the urothelium.

Among the tumors with glandular feature originating in the urinary tract, the following histologic subtypes are recognized: adenocarcinoma not otherwise specified (NOS), enteric, mucinous, signet ring cell, hepatoid, and mixed; tumors of Mullerian type (clear cell and endometrioid adenocarcinomas); and urachal adenocarcinoma. The Mullerian-type neoplasms and urachal adenocarcinoma are characterized by different epidemiologies and natural histories, and they have been discussed separately in the chapters Mullerian-type tumors and urachal carcinoma.

Clinical Features

  • Incidence

    Primary adenocarcinoma of the urinary bladder constitutes 0.5–2% of all bladder malignancies. Intestinal metaplasia and chronic irritation may be related with urinary tract adenocarcinoma (Gordetsky and Epstein 2015; Xin et al. 2016).

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References and Further Reading

  • Alanee, S., Alvarado-Cabrero, I., Murugan, P., et al. (2019). Update of the International Consultation on Urological Diseases on bladder cancer 2018: Non-urothelial cancers of the urinary bladder. World Journal of Urology, 37, 107–114.

    Article  PubMed  Google Scholar 

  • Gordetsky, J., & Epstein, J. I. (2015). Intestinal metaplasia of the bladder with dysplasia: A risk factor for carcinoma? Histopathology, 67, 325–330.

    Article  PubMed  Google Scholar 

  • Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. E. (2016). WHO classification of tumours of the urinary system and male genital organs (pp. 99–107). Lyon: IARC.

    Google Scholar 

  • Rao, Q., Williamson, S. R., Lopez-Beltran, A., et al. (2013). Distinguishing primary adenocarcinoma of the urinary bladder from secondary involvement by colorectal adenocarcinoma: Extended immunohistochemical profiles emphasizing novel markers. Modern Pathology, 26, 725–732.

    Article  CAS  PubMed  Google Scholar 

  • Xin, Z., Zhao, C., Huang, T., et al. (2016). Intestinal metaplasia of the bladder in 89 patients: A study with emphasis on long-term outcome. BMC Urology, 16, 24.

    Article  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region (Ancona), United Hospitals Ancona, Ancona, Italy

    Alessia Cimadamore & Rodolfo Montironi

  3. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  4. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

Authors
  1. Maria Rosaria Raspollini
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  2. Alessia Cimadamore
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  3. Rodolfo Montironi
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  4. Antonio Lopez-Beltran
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Corresponding author

Correspondence to Maria Rosaria Raspollini .

Editor information

Editors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

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Raspollini, M.R., Cimadamore, A., Montironi, R., Lopez-Beltran, A. (2020). Urinary Tract Adenocarcinoma. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4971

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  • DOI: https://doi.org/10.1007/978-3-030-41894-6_4971

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41893-9

  • Online ISBN: 978-3-030-41894-6

  • eBook Packages: MedicineReference Module Medicine

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