Definition
Unclassified renal cell carcinoma is not a distinct type of renal cell carcinoma but a diagnostic category for tumors which do not fit into any of the recognized subtypes of renal cell carcinoma.
Clinical Features
Incidence
These tumors generally account for 0.7–5.7% of renal cell carcinomas (Moch et al. 2016).
Age
It occurs in any age.
Sex
There is no gender predominance.
Site
There is no site predilection.
Treatment
Radical or partial nephrectomy is the standard of care surgery.
Outcome
Outcome is based on prognostic features such as TNM stage, pathologic grade, and the presence of tumor coagulative necrosis which should be reported. Previous studies suggest that unclassified renal cell carcinomas are usually aggressive neoplasms, mostly based on the fact that they present at an advanced stage. More recent studies suggest that might be of similar aggressiveness to clear cell renal cell carcinoma when matched by pT status.
Macroscopy
No specific gross features associated...
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Lopez-Beltran, A., Kirkali, Z., Montironi, R., et al. (2012). Unclassified renal cell carcinoma: A report of 56 cases. BJU International, 110, 786–793.
Moch, H., Humprey, P. A., Ulbright, T. M., & Reuter, V. E. (2016). WHO classification of Tumours of the urinary system and male genital organs. Lyon: Cancer IARC.
Perrino, C. M., Grignon, D. J., Williamson, S. R., Idrees, M. T., Eble, J. N., & Cheng, L. (2018). Morphological spectrum of renal cell carcinoma, unclassified: An analysis of 136 cases. Histopathology, 72(2), 305–319.
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Caliò, A., Segala, D., Lopez-Beltran, A., Martignoni, G. (2020). Renal Cell Carcinoma, Unclassified. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4963
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DOI: https://doi.org/10.1007/978-3-030-41894-6_4963
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