Synonyms
Spermatocytic seminoma (not recommended); Type III germ cell tumor
Definition
A tumor composed of cells with filamentous nuclear chromatin resembling spermatocytes: initially named spermatocytic seminoma (Masson 1946). In the 2016 WHO classification, the name has been changed to spermatocytic tumor (ST), being derived from postpubertal type germ cells, most commonly spermatogonia or early primary spermatocytes (Moch et al. 2016). Nowadays, both the synonyms are used (Hu et al. 2019).
Clinical Features
Incidence
Spermatocytic tumor accounts for about 1% of testicular germ cell tumors.
Age
The more frequently reported age of incidence is the sixth decade of life (age range 19–92 years), a significantly more advanced age than that of all the other germ cell tumors.
Sex
Male.
Site
Bilateral involvement occurs in 9% of cases. Never ST has been reported in extragonadal sites.
Treatment
Orchiectomy
Outcome
ST is only rarely reported with metastases, unless there is tumor...
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References and Further Reading
Hu, R., Ulbright, T. M., & Young, R. H. (2019). Spermatocytic Seminoma: A Report of 85 Cases Emphasizing Its Morphologic Spectrum Including Some Aspects Not Widely Known. The American Journal of Surgical Pathology, 43(1), 1–11.
Kao, C. S., Badve, S. S., & Ulbright, T. M. (2014). The utility of immunostaining for NUT, GAGE7 and NY-ESO-1 in the diagnosis of spermatocytic seminoma. Histopathology, 65(1), 35–44.
Lombardi, M., Valli, M., Brisigotti, M., & Rosai, J. (2011). Spermatocytic seminoma: review of the literature and description of a new case of the anaplastic variant. International Journal of Surgical Pathology, 19(1), 5–10.
Looijenga, L. H., Hersmus, R., Gillis, A. J., Pfundt, R., Stoop, H. J., van Gurp, R. J., Veltman, J., Beverloo, H. B., van Drunen, E., van Kessel, A. G., Pera, R. R., Schneider, D. T., Summersgill, B., Shipley, J., McIntyre, A., van der Spek, P., Schoenmakers, E., & Oosterhuis, J. W. (2006). Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. Cancer Research, 66(1), 290–302.
Masson, P. (1946). Etude sur le seminoma. Review Cancer Biology, 5(4), 361–387.
Mikuz, G., Böhm, G. W., Behrend, M., Schäfer, G., Colecchia, M., & Verdorfer, I. (2014). Therapy-resistant metastasizing anaplastic spermatocytic seminoma: A cytogenetic hybrid: a case report. Analytical and Quantitative Cytopathology and Histopathology, 36(3), 177–182.
Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. E. (2016). WHO classification of tumours of the urinary system and male genital organs (4th ed.). Lyon.
Rosenberg, C., Mostert, M. C., Schut, T. B., van de Pol, M., van Echten, J., de Jong, B., Raap, A. K., Tanke, H., Oosterhuis, J. W., & Looijenga, L. H. (1998). Chromosomal constitution of human spermatocytic seminomas: Comparative genomic hybridization supported by conventional and interphase cytogenetics. Genes, Chromosomes & Cancer, 23(4), 286–291.
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Colecchia, M., Bertolotti, A. (2020). Spermatocytic Tumor. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4950
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DOI: https://doi.org/10.1007/978-3-030-41894-6_4950
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