Uropathology

2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Seminal Vesicle Mixed Epithelial and Stromal Tumors

  • Alessia Cimadamore
  • Rodolfo MontironiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4936
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Synonyms

Cystadenoma; Cystosarcoma phyllodes

Definition

Mixed epithelial and stromal tumors are biphasic tumors with stromal and benign epithelial components (Reikie et al. 2015; McKenney 2018).

Clinical Features

  • Incidence

    Fewer than two dozen cases have been reported.

  • Age

    Patients aged 37–66 years.

  • Sex

    Male.

  • Site

    Seminal vesicles.

  • Treatment

    See outcome.

  • Outcome

    No recurrences of cystadenoma or fibroadenoma have been reported after excision. Adenosarcoma may be curable by cystoprostatectomy or may be incurable and metastatic (Fain et al. 1993; Laurila et al. 1992).

Macroscopy

These cystic to solid masses can be as large as 14 cm in size.

Microscopy

In cystadenoma, gland spaces of various sizes are lined by non-atypical cells, are arranged in a lobular pattern, and form branching lumens and cysts in a spindle cell stroma. Granular intraluminal secretions are usually noted. In fibroadenoma, the stromal component is more pronounced than in cystadenoma. Hypercellular stroma is composed of...
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References and Further Reading

  1. Fain, J. S., Cosnow, I., King, B. F., Zincke, H., & Bostwick, D. G. (1993). Cystosarcoma phyllodes of the seminal vesicle. Cancer, 71(6), 2055–2061.PubMedCrossRefGoogle Scholar
  2. Laurila, P., Leivo, I., Mäkisalo, H., Ruutu, M., & Miettinen, M. (1992). Müllerian adenosarcomalike tumor of the seminal vesicle. A case report with immunohistochemical and ultrastructural observations. Archives of Pathology & Laboratory Medicine, 116(10), 1072–1076.Google Scholar
  3. McKenney, J. K. (2018). Mesenchymal tumors of the prostate. Modern Pathology, 31(S1), S133–S142.PubMedCrossRefGoogle Scholar
  4. Paner, G. P., Lopez-Beltran, A., So, J. S., et al. (2016). Spectrum of cystic epithelial tumors of the prostate: Most cystadenocarcinomas are ductal type with intracystic papillary pattern. American Journal of Surgical Pathology, 40, 886–895.PubMedCrossRefGoogle Scholar
  5. Reikie, B. A., Yilmaz, A., Medlicott, S., et al. (2015). Mixed epithelial-stromal tumor (MEST) of seminal vesicle: A proposal for unified nomenclature. Advances in Anatomic Pathology, 22, 113–120.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute of Pathological Anatomy and HistopathologyPolytechnic University of the Marche Region (Ancona), United Hospitals AnconaAnconaItaly