2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Seminal Vesicle Mixed Epithelial and Stromal Tumors

  • Alessia Cimadamore
  • Rodolfo MontironiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4936


Cystadenoma; Cystosarcoma phyllodes


Mixed epithelial and stromal tumors are biphasic tumors with stromal and benign epithelial components (Reikie et al. 2015; McKenney 2018).

Clinical Features

  • Incidence

    Fewer than two dozen cases have been reported.

  • Age

    Patients aged 37–66 years.

  • Sex


  • Site

    Seminal vesicles.

  • Treatment

    See outcome.

  • Outcome

    No recurrences of cystadenoma or fibroadenoma have been reported after excision. Adenosarcoma may be curable by cystoprostatectomy or may be incurable and metastatic (Fain et al. 1993; Laurila et al. 1992).


These cystic to solid masses can be as large as 14 cm in size.


In cystadenoma, gland spaces of various sizes are lined by non-atypical cells, are arranged in a lobular pattern, and form branching lumens and cysts in a spindle cell stroma. Granular intraluminal secretions are usually noted. In fibroadenoma, the stromal component is more pronounced than in cystadenoma. Hypercellular stroma is composed of...
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References and Further Reading

  1. Fain, J. S., Cosnow, I., King, B. F., Zincke, H., & Bostwick, D. G. (1993). Cystosarcoma phyllodes of the seminal vesicle. Cancer, 71(6), 2055–2061.PubMedCrossRefGoogle Scholar
  2. Laurila, P., Leivo, I., Mäkisalo, H., Ruutu, M., & Miettinen, M. (1992). Müllerian adenosarcomalike tumor of the seminal vesicle. A case report with immunohistochemical and ultrastructural observations. Archives of Pathology & Laboratory Medicine, 116(10), 1072–1076.Google Scholar
  3. McKenney, J. K. (2018). Mesenchymal tumors of the prostate. Modern Pathology, 31(S1), S133–S142.PubMedCrossRefGoogle Scholar
  4. Paner, G. P., Lopez-Beltran, A., So, J. S., et al. (2016). Spectrum of cystic epithelial tumors of the prostate: Most cystadenocarcinomas are ductal type with intracystic papillary pattern. American Journal of Surgical Pathology, 40, 886–895.PubMedCrossRefGoogle Scholar
  5. Reikie, B. A., Yilmaz, A., Medlicott, S., et al. (2015). Mixed epithelial-stromal tumor (MEST) of seminal vesicle: A proposal for unified nomenclature. Advances in Anatomic Pathology, 22, 113–120.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Institute of Pathological Anatomy and HistopathologyPolytechnic University of the Marche Region (Ancona), United Hospitals AnconaAnconaItaly