2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Seminal Vesicle Adenocarcinoma

  • Alessia Cimadamore
  • Liang Cheng
  • Rodolfo MontironiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4935


Primary seminal vesicle adenocarcinoma (PSVA) is an extremely rare malignancy ranging from well-differentiated adenocarcinoma forming papillary structures to poorly differentiated histology. PSVA should be localized exclusively or mainly to the seminal vesicle and a secondary origin from prostate, colon, or bladder should be excluded (Campobasso et al. 2012; Lote et al. 2013).

Clinical Features

  • Incidence

    Only approximately 60 cases have been reported to date.

  • Age

    The age of onset is quite varied, ranging from 19 to 90 years old.

  • Sex


  • Site

    Seminal vesicle.

  • Treatment

    Currently, there is no established guideline for the treatment of seminal vesicle adenocarcinoma. Complete resection appears to offer the best chance for therapy but hormonal manipulation and radiotherapy seem to be effective as adjuvant treatment modalities (Thyavihally et al. 2007; Yin and Jiang 2018).

  • Outcome

    Prognosis is poor, with survival usually <3 years (Thyavihally et al. 2007; Yin and Jiang 2018).


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References and Further Reading

  1. Campobasso, D., Fornia, S., Ferretti, S., et al. (2012). Primary bilateral seminal vesicle carcinoma: Description of a case and literature review. International Journal of Surgical Pathology, 20, 633–635.PubMedCrossRefGoogle Scholar
  2. Lote, H., Mannion, E., Cook, T., et al. (2013). Adenocarcinoma of the seminal vesicles complicated by antineutrophil cytoplasmic antibody vasculitis: A case report and review of the literature. Journal of Medical Case Reports, 7, 59.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Ohmori, T., Okada, K., Tabei, R., et al. (1994). CA125-producing adenocarcinoma of the seminal vesicle. Pathology International, 44, 333–337.PubMedCrossRefGoogle Scholar
  4. Ormsby, A. H., Haskell, R., Jones, D., et al. (2000). Primary seminal vesicle carcinoma: A immunohistochemical analysis of four cases. Modern Pathology, 13, 46–51.PubMedCrossRefGoogle Scholar
  5. Thyavihally, Y. B., Tongaonkar, H. B., Gupta, S., et al. (2007). Primary seminal vesicle adenocarcinoma presenting as isolated metastasis to penis responding to chemotherapy and hormonal therapy. Urology, 69, 778e1–778e3.CrossRefGoogle Scholar
  6. Yin, T., & Jiang, Y. (2018). A 5-year follow-up of primary seminal vesicle adenocarcinoma: A case report. Medicine (Baltimore), 97(41), e12600.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Alessia Cimadamore
    • 1
  • Liang Cheng
    • 2
  • Rodolfo Montironi
    • 1
    Email author
  1. 1.Institute of Pathological Anatomy and HistopathologyPolytechnic University of the Marche Region (Ancona), United Hospitals AnconaAnconaItaly
  2. 2.Department of Pathology and Laboratory MedicineIndiana University School of MedicineIndianapolisUSA