2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Sclerosing Lipogranuloma

  • Cecilia Taverna
  • Alessandro FranchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4933


Eosinophilic sclerosing lipogranuloma; Paraffinoma


Sclerosing lipogranuloma (SLG) is a rare, reactive lesion, with both primary idiopathic and secondary traumatic origin, composed by granulomatous inflammation consequent to injury of the adipose tissue.

Clinical Features

  • Incidence

    Sclerosing lipogranuloma is a rare lesion, with most cases reported as secondary to foreign material injection of oil-based substances in the external genitalia. Idiopathic cases are exceeding rare (Ricchiuti et al. 2012; Ohtsuki et al., 2007; Foxton et al., 2011; Singam et al. 2010).

  • Age

    Sclerosing lipogranuloma can occur at all ages. In particular, if the lesion is secondary to injection of foreign substances, it is more likely to occur in young adults (Ricchiuti et al. 2012; Ohtsuki et al. 2007; Foxton et al. 2011; Singam et al. 2010).

  • Sex

    The lesion typically occurs in male genital region.

  • Site

    Most common sites of occurrence comprise perineal region and scrotum, but sclerosing...

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References and Further Reading

  1. Foxton, G., Vinciullo, C., Tait, C. P., & Sinniah, R. (2011). Sclerosing lipogranuloma of the penis. Australian Journal of Dermatology, 52(3), e12–e14.CrossRefGoogle Scholar
  2. Ohtsuki, Y., Miyazaki, J., Kamei, Y., Yonezawa, M., Sugamoto, T., & Furihata, M. (2007). Three cases of sclerosing lipogranuloma: An immunohistochemical study. Medical Molecular Morphology. Jun, 40(2), 108–111.PubMedCrossRefGoogle Scholar
  3. Ricchiuti, V. S., Richman, M. B., Haas, C. A., Desai, D., & Cai, D. X. (2012). Sclerosing lipogranuloma of the testis. Urology, 60(3), 515.CrossRefGoogle Scholar
  4. Singam, P., Suriyani, L., Ho, C., Eng Hong, G., & Zainuddin, Z. (2010). Primary sclerosing lipogranuloma: An unusual scrotal mass. Libyan Journal of Medicine, 4, 5.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Health SciencesUniversity of FlorenceFlorenceItaly
  2. 2.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly