2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Rete Testis Dysgenesis

  • Manuel NistalEmail author
  • Pilar González-Peramato
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4929


The term rete testis dysgenesis refers to the presence of a rete testis with infantile characteristics in the adult, absence of development of the rete testis cavities, and persistence of a cubic epithelium instead of the squamous epithelium of the adult. It is associated in many cases with a ductal, pseudoglandular, or papillary proliferation of this epithelium.

Clinical Features

It is a histological finding in the study of undescended testes, and in some testes with germ cell tumors.
  • Incidence

    Frequent in the undescended testes removed in the adult (Nistal et al. 1997).

  • Age

    It is a lesion preferably of adults although congenital forms are also observed.

  • Sex


  • Site

    Both testes. No predilection of laterality.

  • Treatment

    No treatment.

  • Outcome

    It is a benign process that probably has its beginning in fetal life due to its association with undescended testes or germ cell tumors, so it should be included among the histological lesions of the testes with testicular dysgenesis...

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References and Further Reading

  1. Nistal, M., & Paniagua, R. (1988). Adenomatous hyperplasia of the rete testis. The Journal of Pathology, 154, 343–346.PubMedCrossRefGoogle Scholar
  2. Nistal, M., & Jiménez-Heffernan, J. A. (1997) Rete testis dysgenesis. A characteristic lesion of undescended testes. Arch Pathol Lab Med, 121, 1259–64.Google Scholar
  3. Nistal, M., Castillo, M. C., Regadera, J., & García-Cabezas, M. A. (2003). Adenomatous hyperplasia of the rete testis. A review and report of new cases. Histology and Histopathology, 18, 741–752.PubMedGoogle Scholar
  4. Nistal, M., Gonzalez-Peramato, P., & Serrano, A. (2017). Rete testis dysgenesis as a marker of undescended testis. In Clues in the diagnosis of non-tumoral testicular pathology (pp. 253–260). Cham: Springer.CrossRefGoogle Scholar
  5. Paluru, S., Ulbright, T. M., Amin, M., Montironi, R., & Epstein, J. I. (2018). The morphologic spectrum of sertoliform cystadenoma of the rete testis: A series of 15 cases. The American Journal of Surgical Pathology, 42, 141–149.PubMedCrossRefGoogle Scholar
  6. Roosen-Runge, E. C., & Holstein, A. F. (1978). The human rete testis. Cell and Tissue Research, 189, 409–433.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Anatomy, Histology and Neuroscience, School of MedicineUniversidad Autónoma de MadridMadridSpain
  2. 2.Department of PathologyUniversidad Autónoma de MadridMadridSpain
  3. 3.Department of PathologyUniversity Hospital La PazMadridSpain