2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Renomedullary Interstitial Cell Tumor of the Kidney

  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4928


Medullary fibroma


Renomedullary interstitial cell tumor is a benign renal lesion. It is still unclear whether it is a hyperplastic lesion arising in response to hypertension or a benign neoplasm.

Clinical Features

  • Incidence

    They are present in nearly 50% of adults and frequently are multiple. They are common autopsy findings (Lerman et al. 1972).

  • Age

    They affect adults and elderly. Rare in pediatric age.

  • Sex

    There is no gender predominance.

  • Site

    Renomedullary interstitial cell tumors are small lesions located in the medulla kidneys.

  • Treatment

    They are found incidentally in autopsies or nephrectomies performed for other tumors.

  • Outcome

    Renomedullary interstitial cell tumors are benign lesions.

Although renomedullary interstitial cells play a role in regulation of blood pressure, renomedullary interstitial cell tumors have no correlation with hypertension.


The tumor is usually 1–5 mm in diameter as white or pale gray nodules within a renal medulla (Lerman...

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References and Further Reading

  1. Caliò, A., Warfel, K. A., & Eble, J. N. (2016). Renomedullary interstitial cell tumors: Pathologic features and clinical correlations. The American Journal of Surgical Pathology, 40, 1693–1701.PubMedCrossRefGoogle Scholar
  2. Lerman, R. J., Pitcock, J. A., Stepherson, P., et al. (1972). Renomedullary interstitial cell tumor (formerly fibroma of the renal medulla). Human Pathology, 3, 559–568.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly