Renal Mucinous Tubular and Spindle Cell Carcinoma

Definition

Renal cell tumor characterized by tubular formations merging with bland spindle cells in a myxoid stroma.

Clinical Features

• Incidence

  This tumor accounts for less than 1% of all renal neoplasms.

• Age

  It arises during the sixth decade of live.

• Sex

  There is a female predilection (M:F = 1:3).

• Site

  There is no site predilection.

• Treatment

  Partial or radical nephrectomy is the treatment of choice.

• Outcome

  Only rare cases have metastasized to lymph nodes and have shown sarcomatoid dedifferentiation.

Macroscopy

The tumor is solid, pale tan to yellow that may have slight focal areas of necrosis or hemorrhage.

Microscopy

Mucinous tubular and spindle cell carcinoma is circumscribed and composed of branching, elongated tubules in a bubbly, basophilic, myxoid stroma (Fig. 1). Tumor cells are predominantly cuboidal with scant, clear to pale, acidophilic cytoplasms and low-grade nucleolar features (Ferlicot et al. 2005).

Renal Mucinous Tubular and Spindle Cell Carcinoma, Fig. 1

Elongated...