Uropathology

2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Renal Mucinous Tubular and Spindle Cell Carcinoma

  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4926
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Definition

Renal cell tumor characterized by tubular formations merging with bland spindle cells in a myxoid stroma.

Clinical Features

  • Incidence

    This tumor accounts for less than 1% of all renal neoplasms.

  • Age

    It arises during the sixth decade of live.

  • Sex

    There is a female predilection (M:F = 1:3).

  • Site

    There is no site predilection.

  • Treatment

    Partial or radical nephrectomy is the treatment of choice.

  • Outcome

    Only rare cases have metastasized to lymph nodes and have shown sarcomatoid dedifferentiation.

Macroscopy

The tumor is solid, pale tan to yellow that may have slight focal areas of necrosis or hemorrhage.

Microscopy

Mucinous tubular and spindle cell carcinoma is circumscribed and composed of branching, elongated tubules in a bubbly, basophilic, myxoid stroma (Fig. 1). Tumor cells are predominantly cuboidal with scant, clear to pale, acidophilic cytoplasms and low-grade nucleolar features (Ferlicot et al. 2005).
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References and Further Reading

  1. Cossu-Rocca, P., Eble, J. N., Delahunt, B., et al. (2006). Renal mucinous tubular and spindle carcinoma lacks the gains of chromosomes 7 and 17 and losses of chromosome Y that are prevalent in papillary renal cell carcinoma. Modern Pathology, 19, 488–493.PubMedCrossRefGoogle Scholar
  2. Ferlicot, S., Allory, Y., Compérat, E., et al. (2005). Mucinous tubular and spindle cell carcinoma: A report of 15 cases and a review of the literature. Virchows Archiv, 447, 978–983.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly