High-Grade Prostatic Intraepithelial Neoplasia
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Intraductal dysplasia of the prostate (obsolete)
High-grade prostatic intraepithelial neoplasia (HGPIN) is a neoplastic proliferation of secretory cells within preexisting ducts and acini, with cytological changes resembling those seen in cancer. HGPIN is the most likely precursor of prostatic adenocarcinoma, according to virtually all available evidence.
The mean incidence of HGPIN in prostatic needle biopsies is about 5%.
Patients aged 50–60 years.
The most commonly location is in the peripheral zone of the prostate.
Treatment is not indicated. Prophylactic RP or radiation is not an acceptable treatment. Patients with isolated HGPIN in needle biopsy may be considered for enrolment into clinical trials with chemoprevention agents. Men with a single core positive for HGPIN do not require routine repeat biopsy. In multifocal HGPIN, follow-up monitoring could include serum and urine tests or imaging.
References and Further Reading
- Moch, H., Humphrey, P. A., Ulbrigh, T. M., & Reutere, V. E. (Eds.). (2016). WHO classification of Tumours of the urinary system and male genital organs. Lyon: International Agency for Research on Cancer.Google Scholar