Synonyms
Endometrioid carcinoma of the prostate (Obsolete) (Melicow and Tannenbaum 1971)
Definition
Ductal adenocarcinoma is a subtype of prostatic adenocarcinoma with large glands lined by tall pseudostratified columnar cells (Zhou 2018).
Clinical Features
Incidence
Pure ductal adenocarcinoma is only seen in 0.2–0.4% of prostate cancers. In most cases, this subtype is combined with acinar adenocarcinoma.
Age
Mainly among patients aged 60–70 years.
Sex
Male.
Site
Tumors are commonly located in the periurethral area but often extends into the periphery of the prostate and is sometimes only seen peripherally.
Treatment
Similar to those of usual acinar adenocarcinoma
Outcome
Ductal adenocarcinoma is more aggressive than the average acinar adenocarcinoma, usually present with higher-stage disease. Rate of death similar to men with Gleason 4 + 4 = 8 acinar adenocarcinoma (Aydin et al. 2010).
Macroscopy
Periurethral cancers often protrude into the urethra as exophytic friable polypoid or...
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References and Further Reading
Aydin, H., Zhang, J., Samaratunga, H., et al. (2010). Ductal adenocarcinoma of the prostate diagnosed on transurethral biopsy or resection is not always indicative of aggressive disease: implications for clinical management. BJU International, 105, 476–480.
Melicow, M. M., & Tannenbaum, M. (1971). Endometrial carcinoma of uterus masculinus (prostatic utricle). Report of 6 cases. The Journal of Urology, 106, 892–902.
Seipel, A. H., Samaratunga, H., Delahunt, B., Wiklund, F., Wiklund, P., Lindberg, J., et al. (2014). Immunohistochemical profile of ductal adenocarcinoma of the prostate. Virchows Archiv, 465(5), 559–565.
Seipel, A. H., Whitington, T., Delahunt, B., et al. (2017). Genetic profile of ductal adenocarcinoma of the prostate. Human Pathology, 69, 1–7.
Zhou, M. (2018). High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal carcinoma of the prostate. Modern Pathology, 31(S1), S71–S79.
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Cimadamore, A., Lopez-Beltran, A., Montironi, R. (2020). Prostatic Ductal Carcinoma. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4913
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DOI: https://doi.org/10.1007/978-3-030-41894-6_4913
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