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Uropathology pp 271Cite as

Penile Clear Cell Carcinoma

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Clear cell squamous cell carcinoma

Definition

Penile clear cell carcinoma (PCCC) is an aggressive human papillomavirus (HPV)-related tumor predominantly composed of clear cells.

Clinical Features

This very unusual tumor shows regional metastases and a tumor mortality exceeding 20% of the cases (Sanchez et al. 2016). PCCC occurs as large, irregular masses on the foreskin or glans.

Microscopy

PCCC has a predominant nesting growth pattern with comedonecrosis in central part of nests and comedo-like necrosis; there are clear cell features in cells with irregular or eccentric nuclei. The presence of HPV is diffused throughout the tumor. Intraepithelial neoplasia with warty or basaloid features can be found.

Differential Diagnosis

Warty Carcinoma with Prominent Clear Cells

The main differential feature is the papillary pattern of growth in warty carcinoma that is not observed in PCCC, where the growth pattern is in solid sheets or nests.

Basaloid Carcinoma

The presence of nesting...

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References and Further Reading

  • Liegl, B., & Regauer, S. (2004). Penile clear cell carcinoma: A report of 5 cases of a distinct entity. The American Journal of Surgical Pathology, 28(11), 1513–1517.

    Article  PubMed  Google Scholar 

  • Sanchez, D. F., Rodriguez, I. M., Piris, A., Cañete, S., Lezcano, C., Velazquez, E. F., Fernandez-Nestosa, M. J., Mendez-Pena, J. E., Hoang, M. P., & Cubilla, A. L. (2016). Clear cell carcinoma of the penis: An HPV-related variant of squamous cell carcinoma: A report of 3 cases. The American Journal of Surgical Pathology, 40(7), 917–922.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Uropathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Maurizio Colecchia

  2. Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

    Alessia Bertolotti

Authors
  1. Maurizio Colecchia
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  2. Alessia Bertolotti
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Corresponding author

Correspondence to Maurizio Colecchia .

Editor information

Editors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

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Cite this entry

Colecchia, M., Bertolotti, A. (2020). Penile Clear Cell Carcinoma. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4880

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  • DOI: https://doi.org/10.1007/978-3-030-41894-6_4880

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41893-9

  • Online ISBN: 978-3-030-41894-6

  • eBook Packages: MedicineReference Module Medicine

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