2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran


  • Raffaele Gaeta
  • Alessandro FranchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4866


Osteogenic sarcoma


Malignant tumor with variable degree of osteoid production by neoplastic cells.

Clinical Features

  • Incidence

    Osteosarcoma is a rare neoplasm, representing about 0.2% of all malignant tumors. The estimated incidence is of three cases/million population/year.

  • Age

    The peak of incidence is between 10 and 25 years of age, while is rare before age 5. Adults over 50 years could be also affected, in particular, in association with risk factors (e.g., post-radiation or Paget disease of bone).

  • Sex

    Males are affected more frequently than females (male: female ratio 1.4:1).

  • Site

    The tumor is usually located in the metaphysis of long bones (distal femur, proximal tibia, and proximal humerus). It is occasionally seen in diaphysis (<9%) and, rarely, in epiphyseal region. It is less common in flat or short bones. In male genital organs, cases of osteosarcoma have been rarely observed. In the English literature, there are reports of five cases of testicular primary...

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References and Further Reading

  1. Al-Masri, A., Al-Shraim, M., Al-Samen, A. A., Chetty, R., & Evans, A. (2007). Primary paratesticular osteosarcoma: Case report and a review of the literature. TSW Urology, 2, 124–128.CrossRefGoogle Scholar
  2. Beiswanger, J. C., Woodruff, R. D., Savane, P. D., & Assimos, D. G. (1997). Primary osteosarcoma of the spermatic cord with synchronous bilateral renal cell carcinoma. Urology, 49, 957–959.CrossRefGoogle Scholar
  3. Hong, R., Lee, G., Kim, H., Kim, C. S., & Kee, K. H. (2011). Primary paratesticular osteosarcoma: A case report. Oncology Letters, 3(3), 554–556.CrossRefGoogle Scholar
  4. Spirtos, G., Abdu, R. A., & Schaub, C. R. (1991). Osteosarcoma of the spermatic cord. The Journal of Urology, 145, 832–833.CrossRefGoogle Scholar
  5. Tazi, H., Karmouni, T., Ouali, M., et al. (2006). Osteosarcoma of the testis. International Journal of Urology, 13, 323–324.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly