2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran


  • Cecilia Taverna
  • Alessandro FranchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4864


Neurofibroma is a benign peripheral nerve sheath tumor arising from cranial, peripheral, or visceral nerves. It can be sporadic or associated to neurofibromatosis.

Clinical Features

  • Incidence

    Neurofibroma is a rare lesion in the genitourinary tract, especially when sporadic. There are approximately 70 reported cases of neurofibroma associated with neurofibromatosis type 1 (NF1) arising in the bladder (Hosseini et al. 2016). Scrotal and spermatic cord neurofibromas are very rare, with 14 cases reported so far, sometimes with an unclear sublocalization due to the anatomical overlap of structures in this region (Boto et al. 2015). Penile neurofibromas are exceedingly rare (Moch et al. 2016).

  • Age

    Neurofibroma can occur both in pediatric and adult populations, with a strict relation between plexiform neurofibromas and pediatric age.

  • Sex

    In the bladder there is no sex predilection, while in external genitalia neurofibromas associated with NF1 are most frequently reported in...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Boto, J., Boudabbous, S., Lobrinus, J. A., Gourmaud, J., & Terraz, S. (2015). Solitary neurofibroma of the spermatic cord: A case report. Journal of radiology case reports, 9(6), 19–28.CrossRefGoogle Scholar
  2. Hornick J. L. (Ed). (2013). Spindle cell tumors of adults. In: Practical soft tissue pathology. A diagnostic approach. Philadelphia: Elsevier Saunders.Google Scholar
  3. Hosseini, S. Z., Alizadeh, F., & Ghana’at, I. (2016). Isolated bladder neurofibroma: A case report and review of literature. Remed Open Access, 1, 1012.Google Scholar
  4. Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. E. (2016). Mesenchymal tumours of penis. In WHO classification of tumours of the urinary system and male genital organs (4th ed.). Lyon: IARC.Google Scholar
  5. Pascual-Castroviejo, I., Lopez-Pereira, P., Savasta, S., Lopez-Gutierrez, J. C., Lago, C. M., & Cisternino, M. (2008). Neurofibromatosis type 1 with external genitalia involvement: Presentation of 4 patients. Journal of Pediatric Surgery, 43, 1998–2003.CrossRefGoogle Scholar
  6. Zugail, A. S., Benadiba, S., Ferlicot, S., & Irani, J. (2017). Oddities sporadic neurofibroma of the urinary bladder. A case report. Urology case reports, 14, 42–44.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Health SciencesUniversity of FlorenceFlorenceItaly
  2. 2.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly