2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Neuroendocrine Tumors of the Kidney

  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4863


Neoplasms occurring within the renal parenchyma showing neuroendocrine differentiation by morphology and immunohistochemistry.

Kidney neoplasms with neuroendocrine differentiation include:
  • Well-differentiated neuroendocrine tumor (carcinoid and atypical carcinoid tumor)

  • Small cell neuroendocrine carcinoma

  • Large cell neuroendocrine carcinoma

Clinical Features

  • Incidence

    Neuroendocrine tumor in the kidney is an uncommon neoplasia. The most common neuroendocrine tumor in renal parenchyma is carcinoid (Lane et al. 2007; Hansel et al. 2007). For small cell carcinoma, primary tumor of renal pelvis and metastases should be rule out. Up to 20% of primary renal carcinoids have been reported in “horseshoe” kidneys.

  • Age

    The majority of the cases have been reported in the fourth to seventh decade.

  • Sex

    No gender predominance.

  • Site

    No specific site in the kidney.

  • Treatment

    Surgical treatment in patients with gross hematuria and abdominal pain

  • Outcome

    The outcome depends on prognostic...

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References and Further Reading

  1. Hansel, D. E., Epstein, J. I., Berbescu, E., et al. (2007). Renal carcinoid tumor: A clinicopathologic study of 21 cases. The American Journal of Surgical Pathology, 31, 1539–1544.CrossRefGoogle Scholar
  2. Lane, B. R., Chery, F., Jour, G., et al. (2007). Renal neuroendocrine tumours: A clinicopathological study. BJI International, 100, 1030–1035.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly