2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran


  • Cecilia Taverna
  • Alessandro FranchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4858


Leiomyoma of the glans penis; Myofibroma of the glans penis


Myointimoma is a rare but very distinctive benign intravascular myofibroblast proliferation, derived from intimal cells of the vessels that constitute the corpus spongiosum of the penis.

Clinical Features

  • Incidence

    Myointimoma is very rare, with only few cases reported so far, including a series of 10 cases (Fetsch et al. 2000), a series of 5 juvenile cases (McKenney et al. 2007), and 4 case reports (Robbins and Kohler 2005; Vardar et al. 2007; Turner et al. 2009; Monsálvez et al. 2009).

    Moreover, it is possible that some old reports of penile intravascular leiomyoma, intravascular leiomyomatosis, leiomyoma, late stage intravascular fasciitis, and solitary cutaneous myofibroma are lesions that would now be called myointimoma (McKenney et al. 2007).

  • Age

    Myointimoma can occur both in the pediatric (Fetsch et al. 2000; McKenney et al. 2007; Turner et al. 2009) and adult population (Fetsch et al. 2000; Robbins...

This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Fetsch, J. F., Brinsko, R. W., Davis, C. J., Jr., Mostofi, F. K., & Sesterhenn, I. A. (2000). A distinctive myointimal proliferation (‘myointimoma’) involving the corpus spongiosum of the glans penis: A clinicopathologic and immunohistochemical analysis of 10 cases. The American Journal of Surgical Pathology, 24(11), 1524–1530.PubMedCrossRefGoogle Scholar
  2. McKenney, J. K., Collins, M. H., Carretero, A. P., Boyd, T. K., Redman, J. F., & Parham, D. M. (2007). Penile myointimoma in children and adolescents: A clinicopathologic study of 5 cases supporting a distinct entity. The American Journal of Surgical Pathology, 31(10), 1622–1626.PubMedCrossRefGoogle Scholar
  3. Monsálvez, V., Rodríguez-Peralto, J. L., Fuertes, L., Garrido, C., & López-Gómez, S. (2009). Myointimoma: A rare tumor of the penis. Actas Dermosifiliográficas, 100(6), 511–512.CrossRefGoogle Scholar
  4. Robbins, J. B., & Kohler, S. (2005). Penile nodule in a 54-year-old man: A case of a myointimoma. Journal of the American Academy of Dermatology, 53(6), 1084–1086.PubMedCrossRefGoogle Scholar
  5. Turner, B. M., Reith, J. D., & Al-Quran, S. Z. (2009). Penile myointimoma. Journal of Cutaneous Pathology, 36(7), 817–819.  https://doi.org/10.1111/j.1600-0560.2008.01138.x.CrossRefPubMedGoogle Scholar
  6. Vardar, E., Gunlusoy, B., Arslan, M., & Kececi, S. (2007). Myointimoma of the glans penis. Pathology International, 57(3), 158–161.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Health SciencesUniversity of FlorenceFlorenceItaly
  2. 2.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly