Definition
Myoid gonadal stromal tumor (MGST) is an emerging entity described in the WHO classification edited in 2016 (Moch et al. 2016) as neoplasm with “spindle-shaped cells showing features of smooth muscle and gonadal stroma.”
Clinical Features
Incidence
It is a rare tumor with less than ten cases published.
Age
In the cases published, this tumor occur in young adults, but it was firstly described in a 4-year-old boy (Evans 1977).
Site
It occurs in the testis.
Treatment
Orchiectomy or nodulectomy (if diagnosed after intraoperatory examination).
Outcome
The clinical follow-up provided for all the reported patients were negative for recurrence or metastatic disease.
Macroscopy
The tumors are circumscribed, nonencapsulated intratesticular nodules ranged from 1.2 to 3.5 cm. In the published cases, no macroscopical figure has been provided (Kao and Ulbright 2014).
Microscopy
The tumor cells are uniform, bland, spindle with oval to spindled nuclei, sometimes entrapping at the periphery...
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Evans, H. L. (1977). Unusual gonadal stromal tumor of the testis. Case report with ultrastructural observations. Archives of Pathology & Laboratory Medicine, 101(6), 317–320.
Kao, C. S., & Ulbright, T. M. (2014). Myoid gonadal stromal tumor: A clinicopathologic study of three cases of a distinctive testicular tumor. American Journal of Clinical Pathology, 142(5), 675–682.
Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. E. (2016). WHO classification of tumours of the urinary system and male genital organs (4th ed.). Lyon: IARC.
Zhang, M., Kao, C. S., Ulbright, T. M., & Epstein, J. I. (2013). Testicular fibrothecoma: A morphologic and immunohistochemical study of 16 cases. American Journal of Surgical Pathology, 37(8), 1208–1214.
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Colecchia, M., Bertolotti, A. (2020). Myoid Gonadal Stromal Tumor of the Testis. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4857
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DOI: https://doi.org/10.1007/978-3-030-41894-6_4857
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