Uropathology

2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Myxofibrosarcoma, Genitourinary Tract

  • Alessandro FranchiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4856
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Synonyms

Fibromyxosarcoma; Myxoid fibrosarcoma; Myxoid malignant fibrous histiocytoma

Definition

Myxofibrosarcoma (MFS) is a malignant fibroblastic neoplasm mainly involving the superficial soft tissues of elderly patients, with variably prominent myxoid stroma and cellular pleomorphism.

Clinical Features

  • Incidence

    MFS is a relatively common sarcoma type.

  • Age

    It is the most common sarcoma of adult and elderly patients.

  • Sex

    It shows a slight male predominance.

  • Site

    MFS typically arises in the lower limbs and limb girdles, followed by the upper extremities. It is usually a superficial tumor, involving the subcutis and the dermis, whereas subfascial sites are involved in approximately one third of the patients. True genitourinary MFS have been observed in the penis (Mentzel et al. 1996), whereas cases reported in the kidney, retroperitoneum, spermatic cord, and prostate most likely represent examples of dedifferentiated liposarcoma (Resorlu et al. 2018; Ozkan et al. 2006; Tearada et al. 2012...

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References and Further Reading

  1. Mentzel, T., Calonje, E., Wadden, C., Camplejohn, R. S., Beham, A., Smith, M. A., & Fletcher, C. D. (1996). Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant. The American Journal of Surgical Pathology, 20, 391–405.PubMedCrossRefGoogle Scholar
  2. Ozkan, B., Ozgüroğlu, M., Ozkara, H., Durak, H., & Talat, Z. (2006). Adult paratesticular myxofibrosarcoma: Report of a rare entity and review of the literature. International Urology and Nephrology, 38(1), 5–7.PubMedCrossRefGoogle Scholar
  3. Resorlu, B., Onem, K., & Germiyanoglu, R. C. (2018). Primary myxofibrosarcoma of the kidney. International Urology and Nephrology, 50(1), 79–80.PubMedCrossRefGoogle Scholar
  4. Tearada, H., Nagata, M., Mugiya, S., & Ozono, S. (2012). High-grade myxofibrosarcoma presenting at the spermatic cord after radiotherapy for prostate cancer. BMJ Case Report, 2012. pii:bcr0320126082.Google Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Translational Research and of New Technologies in Medicine and SurgeryUniversity of PisaPisaItaly