2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Multilocular Cystic Renal Neoplasm of Low Malignant Potential

  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4855


This tumor was previously named “multilocular cystic renal cell carcinoma.”


Multicystic tumor with septa containing individual or groups of clear cells with ISUP/WHO 2016 low nucleolar grade (1–2).

Clinical Features

  • Incidence

    This tumor accounts for less than 1% of all renal tumors, usually incidentally discovered.

  • Age

    It occurs in middle-age adults.

  • Sex

    There is no difference between male and female.

  • Site

    There is no site predilection.

  • Treatment

    Partial or radical nephrectomy is the surgical treatment of choice.

  • Outcome

    To date there are no evidence of recurrence or metastasis.


The tumor consists exclusively of variably sized cysts separated by thin septa and filled with clear, serous, or gelatinous fluid (Fig. 1). Solid, grossly discernible tumor mural nodules are incompatible with the diagnosis.
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References and Further Reading

  1. Suzigan, S., López-Beltrán, A., Montironi, R., et al. (2006). Multilocular cystic renal cell carcinoma : A report of 45 cases of a kidney tumor of low malignant potential. American Journal of Clinical Pathology, 125(2), 217–222.PubMedCrossRefGoogle Scholar
  2. Tretiakova, M., Mehta, V., Kocherginsky, M., Minor, A., Shen, S.S., Sirintrapun, S.J., Yao, J.L., Alvarado-Cabrero, I., Antic, T., Eggener, S.E., Picken, M.M., & Paner, G.P. (2018) Predominantly cystic clear cell renal cell carcinoma and multilocular cystic renal neoplasm of low malignant potential form a low-grade spectrum. Virchows Archiv, 473, 85–93. [Epub ahead of print].Google Scholar
  3. Williamson, S. R., Halat, S., Eble, J. N., Grignon, D. J., Lopez-Beltran, A., Montironi, R., Tan, P. H., Wang, M., Zhang, S., Maclennan, G. T., Baldridge, L. A., & Cheng, L. (2012). Multilocular cystic renal cell carcinoma: Similarities and differences in immunoprofile compared with clear cell renal cell carcinoma. The American Journal of Surgical Pathology, 36(10), 1425–1433.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly