2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran


  • Vanessa Henriques
  • Maria Rosaria Raspollini
  • Antonio Lopez-BeltranEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4853


Choristoma of Müllerian-type tissue (Batt et al. 2007) (not recommended).


Müllerianosis is a rare tumor-like entity consisting of an admixture of endocervical, tubaric or endometrial epithelium, with at least two epithelial types present to qualify for the diagnosis of Müllerianosis. The lesion was first described in 1996 by Clement and Young.

Clinical Features

  • Incidence

    Müllerianosis of the urinary tract is a rare lesion and it occurs in approximately 1% of women with endometriosis; the bladder is the organ most frequently involved (Raspollini and Lopez-Beltran 2019). Its pathogenesis is still a source of debate ranging between an embryological origin, metaplasia, and implantation during surgery.

  • Age

    Müllerianosis affects mainly reproductive age women.

  • Sex

    It is a finding mainly in women. Uncommon cases may occur in male patients under long-term estrogen therapy.

  • Site

    This lesion occurs mainly in the dome or posterior wall of the urinary bladder.

  • Treatment


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References and Further Reading

  1. Batt, R. E., Smith, R. A., Buck Louis, G. M., et al. (2007). Mullerianosis. Histology and Histopathology, 22, 1161–1166.PubMedGoogle Scholar
  2. Branca, G., & Barresi, V. (2014). Müllerianosis of the urinary bladder: A rare tumor-like lesion. Archives of Pathology & Laboratory Medicine, 138, 432–436.CrossRefGoogle Scholar
  3. Clement, P. B., & Young, R. H. (1996). Mullerianosis of the urinary bladder. Modern Pathology, 9, 731–737.PubMedGoogle Scholar
  4. Maggiore, U. L. R., Ferrero, S., Candiani, M., et al. (2017). Bladder endometriosis: A systematic review of pathogenesis, diagnosis, treatment, impact on fertility, and risk of malignant transformation. European Urology, 71, 790–807.CrossRefGoogle Scholar
  5. Raspollini, M. R., & Lopez-Beltran, A. (Eds.). (2019). Gynecologic and urologic pathology: Similarities, differences and challenges. Cambridge: Cambridge University Press.  https://doi.org/10.1017/9781316756423. Chapter 26 – Mullerian Lesions of the Bladder: Endometriosis, Endosalpingiosis, Endocervicosis, and Mullerianosis.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Vanessa Henriques
    • 1
  • Maria Rosaria Raspollini
    • 2
  • Antonio Lopez-Beltran
    • 1
    • 3
    Email author
  1. 1.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  2. 2.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain