Uropathology

2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Mullerian Type Tumors

  • Vanessa Henriques
  • Antonio Lopez-Beltran
  • Maria Rosaria RaspolliniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4852
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Synonyms

Clear cell carcinoma or mesonephric carcinoma (outdated term); Endometrioid adenocarcinoma; Tumors of Mullerian type

Definition

  • Mullerian type tumors are tumor with glandular differentiation which show clear cell or endometrioid adenocarcinoma features on histology. They resemble the homonym tumors of the female genital tract.

Clinical Features

  • Incidence

    They are rare tumors, less than 1% of the malignancies of the urinary tract.

  • Age

    They occur in middle-aged and elderly patients.

  • Sex

    Clear cell carcinoma occurs more in the females, with femate-to-male ratio of 2:1.

    Few cases of endometrioid adenocarcinoma have been reported only in female patients in association with endometriosis.

  • Site

    Clear cell carcinoma is more common in urethral diverticulum, in the bladder neck, in the trigone of the bladder, or in a mullerian duct cyst (Novak et al. 1981).

    Endometrioid carcinoma arises from trigone and posterior wall of the bladder where endometriosis is more common.

  • Treatment

    The...

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References and Further Reading

  1. Adeniran, J. A., & Tamboli, P. (2009). Clear cell adenocarcinoma of the urinary bladder a short review. Archives of Pathology & Laboratory Medicine, 133, 987–991.Google Scholar
  2. Alexiev, B. A., & Tavora, F. (2013). Histology and immunohistochemistry of clear cell adenocarcinoma of the urethra: Histogenesis and diagnostic problems. Virchows Archiv, 462(2), 193–201.PubMedCrossRefGoogle Scholar
  3. Garavan, F., Grainger, R., & Jeffers, M. (2004). Endometrioid carcinoma of the urinary bladder complicating vesical Mullerianosis: A case report and review of the literature. Virchows Archiv, 444, 587–589.PubMedCrossRefGoogle Scholar
  4. Herawi, M., Drew, P. A., Pan, C.-C., & Epstein, J. I. (2010). Clear cell adenocarcinoma of the bladder and urethra: Cases diffusely mimicking nephrogenic adenoma. Human Pathology, 41(4), 594–601.PubMedCrossRefGoogle Scholar
  5. Novak, R. W., Raines, R. B., & Sollee, A. N. (1981). Clear cell carcinoma in a Mullerian duct cyst. American Journal of Clinical Pathology, 76, 339–341.PubMedCrossRefGoogle Scholar
  6. Oliva, E., Amin, M. B., Jimenez, R., & Young, R. H. (2002). Clear cell carcinoma of the urinary bladder: A report and comparison of four tumors of mullerian origin and nine of probable urothelial origin with discussion of histogenesis and diagnostic problems. The American Journal of Surgical Pathology, 26, 190–197.PubMedCrossRefGoogle Scholar
  7. Young, R. H., & Scully, R. E. (1985). Clear cell adenocarcinoma of the bladder and urethra. A report of three cases and review of the literature. The American Journal of Surgical Pathology, 9, 816–826.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Vanessa Henriques
    • 1
  • Antonio Lopez-Beltran
    • 1
    • 2
  • Maria Rosaria Raspollini
    • 3
    Email author
  1. 1.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  2. 2.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain
  3. 3.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly