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Uropathology pp 205–208Cite as

MiT Family Translocation Renal Cell Carcinoma

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

t(6;11) renal cell carcinoma; Xp11 translocation renal cell carcinoma

Definition

The new category of MiT family translocation renal cell carcinoma has been included into the World Health Organization (WHO) classification in 2016. The MiT family renal cell carcinoma comprises two different entities: Xp11 translocation renal cell carcinoma harboring TFE3 gene fusions and t(6;11) renal cell carcinoma harboring a MALAT1-TFEB gene fusion.

Clinical Features

  • Incidence

    Xp11 translocation renal cell carcinoma comprises 20–75% of childhood renal cell carcinoma and 1–4% of adult renal cell carcinoma. T (6;11) renal cell carcinoma is an extremely rare variant, less common than the Xp11 renal cell carcinomas; approximately 60 cases documented in the literature.

  • Age

    Although the initial descriptions were in children, Xp11 translocation and t(6,11) renal cell carcinoma may occur in adults in the age range of other renal cell carcinomas.

  • Sex

    There is no gender predilection.

  • ...

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References and Further Reading

  • Argani, P. (2015). MiT family translocation renal cell carcinoma. Seminars in Diagnostic Pathology, 32, 103–113.

    Article  PubMed  Google Scholar 

  • Argani, P., Olgac, S., Tickoo, S. K., et al. (2007). Xp11 translocation renal cell carcinoma in adults: Expanded clinical, pathologic, and genetic spectrum. The American Journal of Surgical Pathology, 31, 1149–1160.

    Article  PubMed  Google Scholar 

  • Caliò, A., Brunelli, M., Segala, D., et al. (2018). t(6;11) renal cell carcinoma: A study of seven cases including two with aggressive behavior, and utility of CD68 (PG-M1) in the differential diagnosis with pure epithelioid PEComa/epithelioid angiomyolipoma. Modern Pathology, 31, 474–487.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Italy

    Anna Caliò & Guido Martignoni

  2. Department of Pathology, Pederzoli Hospital, Peschiera del Garda, Italy

    Diego Segala & Guido Martignoni

Authors
  1. Anna Caliò
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  2. Diego Segala
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  3. Guido Martignoni
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Corresponding author

Correspondence to Guido Martignoni .

Editor information

Editors and Affiliations

  1. Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy

    Maria Rosaria Raspollini

  2. Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

    Antonio Lopez-Beltran

  3. Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain

    Antonio Lopez-Beltran

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Cite this entry

Caliò, A., Segala, D., Martignoni, G. (2020). MiT Family Translocation Renal Cell Carcinoma. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4847

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  • DOI: https://doi.org/10.1007/978-3-030-41894-6_4847

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41893-9

  • Online ISBN: 978-3-030-41894-6

  • eBook Packages: MedicineReference Module Medicine

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