MiT Family Translocation Renal Cell Carcinoma
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t(6;11) renal cell carcinoma; Xp11 translocation renal cell carcinoma
The new category of MiT family translocation renal cell carcinoma has been included into the World Health Organization (WHO) classification in 2016. The MiT family renal cell carcinoma comprises two different entities: Xp11 translocation renal cell carcinoma harboring TFE3 gene fusions and t(6;11) renal cell carcinoma harboring a MALAT1-TFEB gene fusion.
Xp11 translocation renal cell carcinoma comprises 20–75% of childhood renal cell carcinoma and 1–4% of adult renal cell carcinoma. T (6;11) renal cell carcinoma is an extremely rare variant, less common than the Xp11 renal cell carcinomas; approximately 60 cases documented in the literature.
Although the initial descriptions were in children, Xp11 translocation and t(6,11) renal cell carcinoma may occur in adults in the age range of other renal cell carcinomas.
There is no gender predilection.
There is no...
References and Further Reading
- Caliò, A., Brunelli, M., Segala, D., et al. (2018). t(6;11) renal cell carcinoma: A study of seven cases including two with aggressive behavior, and utility of CD68 (PG-M1) in the differential diagnosis with pure epithelioid PEComa/epithelioid angiomyolipoma. Modern Pathology, 31, 474–487.PubMedPubMedCentralCrossRefGoogle Scholar