2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Metastatic Tumors

  • Maria Rosaria RaspolliniEmail author
  • Antonio Lopez-Beltran
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4846


Secondary tumors


Metastatic tumors are malignant neoplasms that involve urologic organs secondarily.

Clinical Features

  • Incidence

    The incidence varies in different organs. Bladder is the most frequent site of secondary involvement along the urinary tract and male genital organs. Metastatic tumors to the bladder are mainly gastric carcinoma, skin tumors, lung and breast carcinoma. Colonic, prostatic, rectal, and cervical carcinomas involve the bladder with direct spread. The secondary involvement of the other genitourinary organs (testis, penis, kidney, and prostate) represents a small numerical entity but a source of stimulating diagnosis for the pathologist. Kidney and testis are mainly involved via hematogenous spread; the most common primary tumors for renal metastases are lung or controlateral kidney carcinomas; while prostatic carcinoma or gastrointestinal tract tumors can metastasize to the testis. Uncommon secondary tumors involving prostate and penis (Giunchi...

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References and Further Reading

  1. Bates, A. W., & Baithun, S. I. (2000). Secondary neoplasms of the bladder are histological mimics of nontransitional cell primary tumours: Clinicopathological and histological features of 282 cases. Histopathology, 36, 32–40.PubMedCrossRefGoogle Scholar
  2. Giunchi, F., Vasuri, F., Valerio, V., et al. (2017). Unusual asymptomatic presentation of bladder cancer metastatic to the penis. Pathology, Research and Practice, 213, 717–720.PubMedCrossRefGoogle Scholar
  3. Scatena, C., Comin, C. E., Lapini, A., & Raspollini, M. R. (2013). Renal metastasis from pulmonary adenocarcinoma – the pathologist’s approach to an uncommon finding: Case report and review of the literature. Applied Immunohistochemistry & Molecular Morphology, 21, 460–463.CrossRefGoogle Scholar
  4. Ulbright, T. M., & Young, R. H. (2008). Metastatic carcinoma to the testis: A clinicopathologic analysis of 26 nonincidental cases with emphasis on deceptive features. The American Journal of Surgical Pathology, 32, 1683–1693.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Maria Rosaria Raspollini
    • 1
    Email author
  • Antonio Lopez-Beltran
    • 2
    • 3
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain