2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Metanephric Tumors

  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4844


The family of metanephric tumors comprises a spectrum of lesions that are derived from the metanephric blastema such as metanephric adenoma, the most frequent, metanephric adenofibroma and the metanephric stromal tumor.

Metanephric Adenoma

Clinical Features

  • Incidence

    Metanephric adenoma of the kidney is an uncommon neoplasm usually discovered incidentally.

  • Age

    Metanephric adenoma occurs during the fifth decade of life. However, it is the most common epithelial neoplasm found in the kidneys of children.

  • Sex

    It occurs most frequently in women.

  • Site

    There is no site predilection.

  • Treatment

    Partial or radical nephrectomy is the treatment of choice.

  • Outcome

    It is a benign neoplasm.

Roughly 10% of patients with this neoplasm present with polycythemia due to increased erythropoietin production.


Metanephric adenoma is usually a single, solid, well-circumscribed nodule with light brown cut surfaces of glassy quality. It is sharply demarcated from adjacent parenchyma....

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References and Further Reading

  1. Argani, P., & Beckwith, J. B. (2000). Metanephric stromal tumor: Report of 31 cases of a distinctive pediatric renal neoplasm. The American Journal of Surgical Pathology, 24, 917–926.PubMedCrossRefGoogle Scholar
  2. Caliò, A., Eble, J. N., Hes, O., et al. (2016). Distinct clinicopathological features in metanephric adenoma harboring BRAF mutation. Oncotarget, 8, 54096–54105.PubMedPubMedCentralCrossRefGoogle Scholar
  3. Davis, C. J., Jr., Barton, J. H., Sesterhenn, I. A., Mostofi, F. K., & Metanephric adenoma. (1995). Clinicopathological study of fifty patients. The American Journal of Surgical Pathology, 19, 1101–1114.PubMedCrossRefGoogle Scholar
  4. Kinney, S. N., Eble, J. N., Hes, O., et al. (2015). Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma. Modern Pathology, 28, 1236–1248.PubMedCrossRefGoogle Scholar

Copyright information

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Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly