Definition
The family of metanephric tumors comprises a spectrum of lesions that are derived from the metanephric blastema such as metanephric adenoma, the most frequent, metanephric adenofibroma and the metanephric stromal tumor.
Metanephric Adenoma
Clinical Features
Incidence
Metanephric adenoma of the kidney is an uncommon neoplasm usually discovered incidentally.
Age
Metanephric adenoma occurs during the fifth decade of life. However, it is the most common epithelial neoplasm found in the kidneys of children.
Sex
It occurs most frequently in women.
Site
There is no site predilection.
Treatment
Partial or radical nephrectomy is the treatment of choice.
Outcome
It is a benign neoplasm.
Roughly 10% of patients with this neoplasm present with polycythemia due to increased erythropoietin production.
Macroscopy
Metanephric adenoma is usually a single, solid, well-circumscribed nodule with light brown cut surfaces of glassy quality. It is sharply demarcated from adjacent parenchyma....
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References and Further Reading
Argani, P., & Beckwith, J. B. (2000). Metanephric stromal tumor: Report of 31 cases of a distinctive pediatric renal neoplasm. The American Journal of Surgical Pathology, 24, 917–926.
Caliò, A., Eble, J. N., Hes, O., et al. (2016). Distinct clinicopathological features in metanephric adenoma harboring BRAF mutation. Oncotarget, 8, 54096–54105.
Davis, C. J., Jr., Barton, J. H., Sesterhenn, I. A., Mostofi, F. K., & Metanephric adenoma. (1995). Clinicopathological study of fifty patients. The American Journal of Surgical Pathology, 19, 1101–1114.
Kinney, S. N., Eble, J. N., Hes, O., et al. (2015). Metanephric adenoma: the utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma. Modern Pathology, 28, 1236–1248.
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Caliò, A., Segala, D., Martignoni, G. (2020). Metanephric Tumors. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4844
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DOI: https://doi.org/10.1007/978-3-030-41894-6_4844
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