2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran


  • Maria Rosaria RaspolliniEmail author
  • Antonio Lopez-Beltran
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4843


Malignant mesothelioma


Malignant tumor arising from the serosal membrane of the tunica vaginalis.

Clinical Features

  • Incidence

    Uncommon tumor.

  • Age

    Mean age 60 years, patients are older than germ cell tumor patients. Rare cases have been reported in children (Khan et al. 1997).

  • Sex


  • Site

    Mesothelioma arises from tunica vaginalis but envelops and invades the testicular parenchyma.

  • Treatment

    Radical inguinal orchiectomy is the treatment of choice. Retroperitoneal lymph-node dissection and postoperative radiotherapy or chemotherapy has been suggested.

  • Outcome

    It is an aggressive tumor, with high recurrence rate and metastatic disease.


It is usually a solid mass causing thickening of the tunica vaginalis in the context of hydrocele with occasional papillae on the surface. The tumor may grossly involve the testis.


Paratesticular mesothelioma shows epithelial pattern in the majority of the cases (70%), or biphasic (30%). The sarcomatoid subtype is...

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References and Further Reading

  1. Butnor, K. J., Sporn, T. A., Hammar, S. P., & Roggli, V. L. (2001). Well-differentiated papillary mesothelioma. The American Journal of Surgical Pathology, 25, 1304–1309.PubMedCrossRefGoogle Scholar
  2. Chekol, S. S., & Sun, C.-C. (2012). Malignant mesothelioma of the tunica vaginalis testis. Diagnostic studies and differential diagnosis. Archives of Pathology & Laboratory Medicine, 136, 113–117.CrossRefGoogle Scholar
  3. Jones, M. A., Young, R. H., & Scully, R. E. (1995). Malignant mesothelioma of the tunica vaginalis. A clinocopathological analysis of 11 cases with review of the literature. The American Journal of Surgical Pathology, 19, 815–825.PubMedCrossRefGoogle Scholar
  4. Khan, M. A., Ruri, P., & Devaney, D. (1997). Mesothelioma of tunica vaginalis in a child. The Journal of Urology, 158, 198–199.PubMedCrossRefGoogle Scholar
  5. Ordonez, N. G. (1999). The immunohistochemical diagnosis of epithelial mesothelioma. Human Pathology, 30, 313–323.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Maria Rosaria Raspollini
    • 1
    Email author
  • Antonio Lopez-Beltran
    • 2
    • 3
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain