2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Median Raphe Cyst

  • Chiara Trambaiolo Antonelli
  • Francesca PortelliEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4841


Genitoperineal raphe cyst; Mucoid cyst of the penile skin; Parameatal cyst


Median raphe cyst is a cyst arising along the midline of the ventral side of the male genital area. It is commonly thought to be secondary to anomalies in fusion between genito-urethral folds and urethral plate. It is mostly asymptomatic, but it can enlarge owing to infection or trauma, or during adolescence, thus interfering with urinary and sexual functions.

Clinical Features

  • Incidence

    It is a rare lesion, with no reported studies about the exact incidence of occurrence.

  • Age

    Median raphe cyst often arises in childhood but may become evident later during growth. This could explain the bimodal peak of incidence in age that has been observed (childhood and young adults).

  • Sex


  • Site

    Median raphe cyst may potentially arise from any site on the ventral side of the genital area, including the parameatus, glans penis, penile shaft, scrotum, and perineum.

  • Treatment

    The suggested treatment is...

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References and Further Reading

  1. Dini, M., Baroni, G., & Maurizio, C. (2001). Median raphe cyst of the penis: A report of two cases with immunohistochemical investigation. American Journal of Dermatopathology, 23, 320–324.PubMedCrossRefGoogle Scholar
  2. Hung, S., Tai-Di, C., Hsiang-Te, S., & Hsiao-Wen, C. (2012). Male median raphe cysts: Serial retrospective analysis and histopathological classification. Diagnostic Pathology, 7, 121.CrossRefGoogle Scholar
  3. Nishida, H., Kashima, K., Daa, T., Yada, N., Arakane, M., Matsuda, K., Kato, A., Shimizu, F., & Yokoyama, S. (2012). Pigmented median raphe cyst of the penis. Journal of Cutaneous Pathology, 8, 808–810.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Chiara Trambaiolo Antonelli
    • 1
  • Francesca Portelli
    • 2
    Email author
  1. 1.Departments of Anatomical Pathology and of Oncology, Ospedale Policlinico San MartinoUniversity of GenoaGenoaItaly
  2. 2.Section of Anatomical Pathology, Department of Health SciencesAzienda Ospedaliero-Universitaria Careggi, University of FlorenceFlorenceItaly