2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Juvenile Xanthogranuloma of the Testis

  • Manuel NistalEmail author
  • Pilar González-Peramato
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4834


Juvenile xanthogranuloma of the testis (JXG) is a rare testicular non-Langerhans cell histiocytosis similar to that which occurs much more frequently in childhood as a skin nodule, although it may affect soft tissues and viscera, including the genitourinary tract in the multifocal and systemic forms (Idrees et al. 2017).

Clinical Features

Testicular tumor that suggests malignancy may or may not be associated with skin lesions.
  • Incidence


  • Age

    It is more frequent in childhood between 2.5 and 13 months. The forms of a single testicular lesion are more frequent than in those associated with manifestations of JXG elsewhere. JXG also occurs in adulthood.

  • Sex


  • Site

    Both testis.

  • Treatment

    Orchiectomy. Not always, but in some cases where partial orchiectomy has been done, the tumor has relapsed.

  • Outcome

    Excellent if it is not associated with similar extratesticular lesions.


The enlarged testicle presents a uniform grayish-yellow coloration to the section.


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References and Further Reading

  1. Idrees, M. T., Ulbright, T. M., Oliva, E., Young, R. H., Montironi, R., Egevad, L., Berney, D., Srigley, J. R., Epstein, J. I., Tickoo, S. K., & Members of the International Society of Urological Pathology Testicular Tumour Panel. (2017). The World Health Organization 2016 classification of testicular non-germ cell tumours: A review and update from the International Society of Urological Pathology Testis Consultation Panel. Histopathology, 70, 513–521.CrossRefGoogle Scholar
  2. Suson, K., Mathews, R., Goldstein, J. D., & Dehner, L. P. (2010). Juvenile xanthogranuloma presenting as a testicular mass in infancy: A clinical and pathologic study of three cases. Pediatric and Developmental Pathology, 13, 39–45.CrossRefGoogle Scholar
  3. Townell, N. H., Gledhill, A., Robinson, T., & Hopewell, P. (1985). Juvenile xanthogranuloma of the testis. The Journal of Urology, 133, 1054–1055.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Anatomy, Histology and Neuroscience, School of MedicineUniversidad Autónoma de MadridMadridSpain
  2. 2.Department of PathologyUniversidad Autónoma de MadridMadridSpain
  3. 3.Department of PathologyUniversity Hospital La PazMadridSpain