Inflammatory Myofibroblastic Tumor
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Inflammatory myofibrohistiocytic proliferation; Inflammatory pseudotumor; Plasma cell granuloma; Pseudosarcomatous myofibroblastic tumor
Inflammatory myofibroblastic tumor (IMT) is a tumor composed of myofibroblasts accompanied by a mixed inflammatory infiltrate.
IMT is a relatively rare tumor in the genitourinary system.
It may occur at all ages, including in children. The mean age at diagnosis is 50 years.
It involves more frequently male subjects.
Genitourinary IMT arise more frequently in the bladder, but cases have been reported also in the kidneys, prostate, spermatic cord, and testis.
In the bladder, most cases are treated with transurethral resection. Some patients have undergone partial cystectomy.
IMT is a locally aggressive neoplasm, with tendency to local recurrence, and rare incidence of metastasis.
Grossly, IMT appears as a circumscribed solitary or multinodular mass with a white to...
References and Further Reading
- Jebastin, J. A. S., Smith, S. C., Perry, K. D., Gupta, N. S., Alanee, S., Carskadon, S., Chitale, D. A., Palanisamy, N., & Williamson, S. R. (2018). Pseudosarcomatous myofibroblastic proliferations of the genitourinary tract are genetically different from nodular fasciitis and lack USP6, ROS1 and ETV6 gene rearrangements. Histopathology, 73, 321–326.CrossRefGoogle Scholar
- Montgomery, E. A., Shuster, D. D., Burkart, A. L., Esteban, J. M., Sgrignoli, A., Elwood, L., Vaughn, D. J., Griffin, C. A., & Epstein, J. I. (2006). Inflammatory myofibroblastic tumors of the urinary tract: A clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma. The American Journal of Surgical Pathology, 30, 1502–1512.CrossRefGoogle Scholar