2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Inflammation of Littre’s Glands

  • Caterina Fattorini
  • Antonio Lopez-Beltran
  • Maria Rosaria RaspolliniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4831


Periurethral gland inflammation


Inflammation of periurethral glands of Littre (tubule-acinar mucinous glands located along the urethra that secrete mucus and are most numerous in the section of the urethra that runs through the penis).

Clinical Features

  • Incidence

    Very rare

  • Age

    Young adults mainly

  • Sex


  • Site and Presentation

    Patients usually report pain or discomfort during urination and urinalysis highlights an increase of leukocytes. Sometimes it presents with a firm small nodule of the penis or urethra (Krawitt and Schechterman 1977).

  • Treatment

    The therapy is symptomatic. If the inflammation process appears as a nodule, excision of the lesion is required due to the differential diagnosis with neoplastic masses.

  • Outcome

    Excellent prognosis


The nodular presentation is more relevant in pathology practice and appears as a small tan nodule. The cut surface displays a honeycomb pattern.


The Littre’s gland lumen is occupied with mucus and...

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References and Further Reading

  1. Goldblum, J., Lamps, L., McKenney, J., & Myers, J. (2017). Rosai and Ackerman’s surgical pathology (11th ed.). Philadelphia: Elsevier.Google Scholar
  2. Krawitt, L. N., & Schechterman, L. (1977). Inflammation of the periurethral glands of Littre simulating tumor. The Journal of Urology, 118, 685.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Caterina Fattorini
    • 1
  • Antonio Lopez-Beltran
    • 2
    • 3
  • Maria Rosaria Raspollini
    • 1
    Email author
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain