2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Idiopathic Granulomatous Epididymitis

  • Maurizio ColecchiaEmail author
  • Alessia Bertolotti
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4828


Idiopathic granulomatous epididymitis (IGE) refers to a lesion of the epididymis requiring a period of ≥6 weeks for the duration of symptoms, while others accept a period of 3 months, with no identifiable etiology (Çek et al. 2017).

Clinical Features

  • Incidence

    Idiopathic granulomatous epididymitis is rare.

  • Age

    It affects the adult male usually 40–59 years old.

  • Sex


  • Site

    Typically unilateral swelling and tenderness of epididymis, usually beginning in the tail and spreading to involve the whole of the epididymis.

  • Treatment

    Some patients who were only medically treated for granulomatous orchitis have recovered, but orchidectomy in cases without a preoperatory diagnosis is the treatment of choice (Morozumi et al. 2018).

  • Outcome

    Patients with a 6 weeks or longer history of discomfort or pain in the epididymis may experience testicular pain generally without any signs of infection; induration involving the spermatic cord could be another symptom.


A mass with small...

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References and Further Reading

  1. Çek, M., Sturdza, L., & Pilatz, A. (2017). Acute and chronic epididymitis. European Urology Supplements, 16, 124–131.CrossRefGoogle Scholar
  2. Morozumi, K., Ozawa, M., Kuromoto, A., Sato, M., Hoshi, S., & Numahata, K. (2018). High orchidectomy and histopathology to differentiate granulomatous orchitis from testicular malignancy: Case report and literature review. Hinyokika Kiyo, 64(2), 75–78.PubMedGoogle Scholar
  3. Nistal, M., Mate, A., & Paniagua, R. (1997). Granulomatous epididymal lesion of possible ischemic origin. American Journal of Surgical Pathology, 21(8), 951–956.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Uropathology Unit, Department of PathologyFondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilanItaly
  2. 2.Department of PathologyFondazione IRCCS Istituto Nazionale dei Tumori di MilanoMilanItaly