Germ Cell Tumors
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Type II germ cell tumor of the testis
Although testicular cancers are rare, accounting for only 1% of all cancers in males, they are the most common malignancy among white young men between puberty and their 40s in industrialized countries (Gatta and Trama 2016). Approximately, 98% of testicular cancers are germ cell tumors (GCTs); the remaining 2% are sex cord tumors or hematopoietic tumors. In the prepubertal period testicular tumors of the testis are rare with annual incidence estimated for 1–2% of all solid pediatric tumors, with germ cell tumors accounting for 71% (yolk sac tumors 49%, teratomas 13%, seminoma and mixed germ cell tumors 9%), while gonadal stromal tumors are 29% of the prepubertal testicular tumors (Ross and Kay 2004). The young average patient age, the bell-shaped age distribution, and the decreased risk for TGCTs among men born in North America and several European populations during World War II are consistent with tumor...
References and Further Reading
- Moch, H., Humphrey, P. A., Ulbright, T. M., & Reuter, V. E. (2016). WHO classification of tumours of the urinary system and male genital organs (4th ed.). Lyon: International Agency for Research on Cancer.Google Scholar
- Skakkebaek, N. E., Holm, M., Hoei-Hansen, C., et al. (2003). Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: Evidence from 20 adult patients with signs of maldevelopment of the testis. Acta Pathologica Microbiologica et Immunologica Scandinavica, 111, 1–9.CrossRefGoogle Scholar