Synonyms
Benign condyloma; Genital wart; Usual condyloma
Definition
HPV-related exophytic papillomatous epithelial proliferation (Calonje 2011).
Clinical Features
Incidence
Median of 200 affected patients per 100,000 inhabitants (male and female) (Patel et al. 2013).
Age
Sexually active young adults (3rd–4thdecade), rare in older patients.
Sex
Male and female adults.
Etiology
Most cases (85%) are related to low-risk HPV genotypes 6 and 11. High risk genotypes (16, 18, and others) are more common in patients with multiple sexual partners.
Site
Glans, coronal sulcus, foreskin, meatus, scrotum (men), and even urethra or urinary bladder (men and women) for direct extension.
Treatment
Cryotherapy, laser therapy, or local surgical excision for small circumscribed lesions. Extensive surgery is required for giant destructive condylomas.
Outcome
Good but recurrence is not uncommon, especially for individuals with multiple sexual partners (Thomas et al. 2017).
Malignant transformation is very...
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Amin, M. B. (2016). Diagnostic pathology: Genitourinary. Philadelphia: Elsevier.
Botella, E., Burgués, O., et al. (2000). Warty carcinoma arising in condyloma acuminatum of urinary bladder: A case report. International Journal of Surgical Pathology, 8(3), 253–259.
Calonje, E. (2011). Mckee’s pathology of the skin. Amsterdam: Elsevier.
Patel, H., Wagner, M., et al. (2013). Systematic review of the incidence and prevalence of genital warts. BMC Infectious Diseases, 13, 39–39.
Thomas, R., Steben, M., et al. (2017). Recurrence of human papillomavirus external genital wart infection among high-risk adults in Montréal, Canada. Sexually Transmitted Diseases, 44(11), 700–706.
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Fattorini, C., Lopez-Beltran, A., Raspollini, M.R. (2020). Condyloma and Condyloma Acuminatum. In: Raspollini, M.R., Lopez-Beltran, A. (eds) Uropathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-41894-6_4793
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DOI: https://doi.org/10.1007/978-3-030-41894-6_4793
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