2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Condyloma and Condyloma Acuminatum

  • Caterina Fattorini
  • Antonio Lopez-Beltran
  • Maria Rosaria RaspolliniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4793


Benign condyloma; Genital wart; Usual condyloma


HPV-related exophytic papillomatous epithelial proliferation (Calonje 2011).

Clinical Features

  • Incidence

    Median of 200 affected patients per 100,000 inhabitants (male and female) (Patel et al. 2013).

  • Age

    Sexually active young adults (3rd–4thdecade), rare in older patients.

  • Sex

    Male and female adults.

  • Etiology

    Most cases (85%) are related to low-risk HPV genotypes 6 and 11. High risk genotypes (16, 18, and others) are more common in patients with multiple sexual partners.

  • Site

    Glans, coronal sulcus, foreskin, meatus, scrotum (men), and even urethra or urinary bladder (men and women) for direct extension.

  • Treatment

    Cryotherapy, laser therapy, or local surgical excision for small circumscribed lesions. Extensive surgery is required for giant destructive condylomas.

  • Outcome

    Good but recurrence is not uncommon, especially for individuals with multiple sexual partners (Thomas et al. 2017).

    Malignant transformation is very...

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References and Further Reading

  1. Amin, M. B. (2016). Diagnostic pathology: Genitourinary. Philadelphia: Elsevier.Google Scholar
  2. Botella, E., Burgués, O., et al. (2000). Warty carcinoma arising in condyloma acuminatum of urinary bladder: A case report. International Journal of Surgical Pathology, 8(3), 253–259.PubMedCrossRefGoogle Scholar
  3. Calonje, E. (2011). Mckee’s pathology of the skin. Amsterdam: Elsevier.Google Scholar
  4. Patel, H., Wagner, M., et al. (2013). Systematic review of the incidence and prevalence of genital warts. BMC Infectious Diseases, 13, 39–39.PubMedPubMedCentralCrossRefGoogle Scholar
  5. Thomas, R., Steben, M., et al. (2017). Recurrence of human papillomavirus external genital wart infection among high-risk adults in Montréal, Canada. Sexually Transmitted Diseases, 44(11), 700–706.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Caterina Fattorini
    • 1
  • Antonio Lopez-Beltran
    • 2
    • 3
  • Maria Rosaria Raspollini
    • 1
    Email author
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain