2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Chromophobe Renal Cell Carcinoma

  • Anna Caliò
  • Diego Segala
  • Guido MartignoniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4790


Chromophobe renal cell carcinoma is composed by cells with prominent cell membranes, wrinkled nuclei with perinuclear halos, and pale to eosinophilic cytoplasm.

Clinical Features

Most tumors are incidentally discovered, can be sporadic, or occur in Birt-Hogg-Dubè syndrome, which is an autosomal dominant genodermatosis due to the mutation in folliculin gene and characterized by the presence of multiple fibrofolliculomas on the skin, acrochordons, trichodiscomas, pulmonary cysts, and multifocal renal tumors.
  • Incidence

    Chromophobe renal cell carcinoma accounts 5% of renal cell carcinoma.

  • Age

    The mean age is 50–60 years.

  • Sex

    There is no difference between male and female.

  • Site

    There is no site predilection.

  • Treatment

    Partial or radical nephrectomy is the surgical treatment of choice, whenever feasible.

  • Outcome

    Most of chromophobe renal cell carcinomas show an indolent behavior.


Grossly, it is a solid, well-circumscribed, unencapsulated neoplasm with a light brown...
This is a preview of subscription content, log in to check access.

References and Further Reading

  1. Brunelli, M., Eble, J. N., Zhang, S., Martignoni, G., Delahunt, B., & Cheng, L. (2005). Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Modern Pathology, 18(2), 161–169.PubMedCrossRefGoogle Scholar
  2. Delahunt, B., Sika-Paotonu, D., Bethwaite, P. B., McCredie, M. R., Martignoni, G., Eble, J. N., & Jordan, T. W. (2007). Fuhrman grading is not appropriate for chromophobe renal cell carcinoma. The American Journal of Surgical Pathology, 31(6), 957–960.PubMedCrossRefGoogle Scholar
  3. Martignoni, G., Pea, M., Chilosi, M., Brunelli, M., Scarpa, A., Colato, C., Tardanico, R., Zamboni, G., & Bonetti, F. (2001). Parvalbumin is constantly expressed in chromophobe renal carcinoma. Modern Pathology, 14(8), 760–767.PubMedCrossRefGoogle Scholar
  4. Przybycin, C. G., Cronin, A. M., Darvishian, F., Gopalan, A., Al-Ahmadie, H. A., Fine, S. W., Chen, Y. B., Bernstein, M., Russo, P., Reuter, V. E., & Tickoo, S. K. (2011). Chromophobe renal cell carcinoma: a clinicopathologic study of 203 tumors in 200 patients with primary resection at a single institution. The American Journal of Surgical Pathology, 35(7), 962–970.PubMedCrossRefGoogle Scholar
  5. Volpe, A., Novara, G., Antonelli, A., Bertini, R., Billia, M., Carmignani, G., Cunico, S. C., Longo, N., Martignoni, G., Minervini, A., Mirone, V., Simonato, A., Terrone, C., Zattoni, F., & Ficarra, V. (2012). Chromophobe renal cell carcinoma (RCC): oncological outcomes and prognostic factors in a large multicentre series. BJU International, 110(1), 76–83.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Diagnostic and Public Health, Section of PathologyUniversity of VeronaVeronaItaly
  2. 2.Department of PathologyPederzoli HospitalPeschiera del GardaItaly