Chromophobe Renal Cell Carcinoma
- 7 Downloads
Chromophobe renal cell carcinoma is composed by cells with prominent cell membranes, wrinkled nuclei with perinuclear halos, and pale to eosinophilic cytoplasm.
Chromophobe renal cell carcinoma accounts 5% of renal cell carcinoma.
The mean age is 50–60 years.
There is no difference between male and female.
There is no site predilection.
Partial or radical nephrectomy is the surgical treatment of choice, whenever feasible.
Most of chromophobe renal cell carcinomas show an indolent behavior.
References and Further Reading
- Brunelli, M., Eble, J. N., Zhang, S., Martignoni, G., Delahunt, B., & Cheng, L. (2005). Eosinophilic and classic chromophobe renal cell carcinomas have similar frequent losses of multiple chromosomes from among chromosomes 1, 2, 6, 10, and 17, and this pattern of genetic abnormality is not present in renal oncocytoma. Modern Pathology, 18(2), 161–169.PubMedCrossRefGoogle Scholar
- Przybycin, C. G., Cronin, A. M., Darvishian, F., Gopalan, A., Al-Ahmadie, H. A., Fine, S. W., Chen, Y. B., Bernstein, M., Russo, P., Reuter, V. E., & Tickoo, S. K. (2011). Chromophobe renal cell carcinoma: a clinicopathologic study of 203 tumors in 200 patients with primary resection at a single institution. The American Journal of Surgical Pathology, 35(7), 962–970.PubMedCrossRefGoogle Scholar
- Volpe, A., Novara, G., Antonelli, A., Bertini, R., Billia, M., Carmignani, G., Cunico, S. C., Longo, N., Martignoni, G., Minervini, A., Mirone, V., Simonato, A., Terrone, C., Zattoni, F., & Ficarra, V. (2012). Chromophobe renal cell carcinoma (RCC): oncological outcomes and prognostic factors in a large multicentre series. BJU International, 110(1), 76–83.PubMedCrossRefGoogle Scholar