2020 Edition
| Editors: Maria Rosaria Raspollini, Antonio Lopez-Beltran

Calcifying Nodules

  • Caterina Fattorini
  • Antonio Lopez-Beltran
  • Maria Rosaria RaspolliniEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-030-41894-6_4788


Scrotum: Idiopathic calcinosis of scrotum; Testis: Nodular proliferation of calcifying connective tissue


Benign condition characterized by presence of single or multiple calcified nodules.

Clinical Features

  • Incidence

    Uncommon condition.

  • Age

    Children and young adults.

  • Sex


  • Site

    Skin of scrotum, testis, and paratesticular structures.

  • Presentation
    • Scrotum: Single or multiple mobile masses affecting the skin of this region.

    • Testis: Single palpable mass of varying size near the pole of the organ.

  • Treatment
    • Scrotum: Surgical excision of the symptomatic nodules is sufficient (Khallouk et al. 2011).

    • Testis: Due to the undefined diagnosis before the final histopathologic examination, a partial orchiectomy is frequently performed (Akdemir et al. 2017).

  • Outcome

    Calcifying nodules are benign lesions and the prognosis after excision is excellent.


Well-circumscribed yellowish nodules, rarely pedunculated (Gi et al. 2008).


Scrotum: Granular and globular...
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References and Further Reading

  1. Akdemir, F., Aldemir, M., & Orhun, H. S. (2017). Intratesticular calcified nodule. Turkish Journal of Urology, 43, 563–565.PubMedPubMedCentralCrossRefGoogle Scholar
  2. Gi, N., Gupta, A. K., Sachi, K., & Thomas, S. (2008). Idiopathic scrotal calcinosis; a pedunculated rare variant. Journal of Plastic, Reconstructive & Aesthetic Surgery, 61, 466–467.CrossRefGoogle Scholar
  3. Khallouk, A., Yazami, O. E., Mellas, S., Tazi, M. F., El Fassi, J., & Farih, M. H. (2011). Idiopathic scrotal calcinosis: A non-elucidated pathogenesis and its surgical treatment. Reviews in Urology, 13, 95–97.PubMedPubMedCentralGoogle Scholar
  4. Nistal, M., & Paniagua, R. (1989). Nodular proliferation of calcifying connective tissue in the rete testis: A study of three cases. Human Pathology, 20, 58–61.PubMedCrossRefGoogle Scholar
  5. Song, D. H., Lee, K. H., & Kang, W. H. (1988). Idiopathic calcinosis of the scrotum: Histopathologic observations of fifty-one nodules. Journal of the American Academy of Dermatology, 19, 1095–1101.PubMedCrossRefGoogle Scholar
  6. Swinehart, J. M., & Golitz, L. E. (1982). Scrotal calcinosis: Dystrophic calcification of epidermoid cysts. Archives of Dermatology, 118, 985–988.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Caterina Fattorini
    • 1
  • Antonio Lopez-Beltran
    • 2
    • 3
  • Maria Rosaria Raspollini
    • 1
    Email author
  1. 1.Histopathology and Molecular DiagnosticsUniversity Hospital CareggiFlorenceItaly
  2. 2.Pathology ServiceChampalimaud Clinical CenterLisbonPortugal
  3. 3.Unit of Anatomic Pathology, Department of SurgeryCordoba University Medical SchoolCordobaSpain